{"id":"W2320379450","doi":"10.1161/circgenetics.113.000298","title":"iPS Cell–Derived Cardiogenicity is Hindered by Sustained Integration of Reprogramming Transgenes","year":2014,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Induced pluripotent stem cell; Reprogramming; Transgene; Biology; Cell biology; KLF4; Embryonic stem cell; Myosin; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004845723,0.0004077935,0.0002762574,0.0001599621,0.0001133446,0.0005765096,0.0002439233,0.0002969766,0.001157215],"category_scores_gemma":[0.0003390656,0.000159661,0.0001850983,0.0001360056,0.0004390307,0.0002978216,0.0003794316,0.0006661955,0.000482181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639138,"about_ca_system_score_gemma":0.0002369405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001375855,"about_ca_topic_score_gemma":0.0001322616,"domain_scores_codex":[0.9994591,0.00008279849,0.00007846855,0.00009929927,0.0002287466,0.00005155097],"domain_scores_gemma":[0.9995703,0.0001343548,0.0001331908,0.00007126234,0.0000529133,0.00003797415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000149975,0.000008842595,0.0002061695,0.0000318603,0.000004799852,0.00004472318,0.00001244777,0.00009005711,0.9982134,0.0001430105,0.00001540572,0.001214298],"study_design_scores_gemma":[0.000004928527,0.0001408285,0.001835138,0.00001149646,0.00002450096,0.0002326593,0.0000128188,0.0009725743,0.9946368,0.0001172533,0.002007235,0.000003649349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728114,0.001376858,0.0235086,0.0001098784,0.00003575948,0.00002868183,0.0002222959,0.0002249532,0.001681657],"genre_scores_gemma":[0.9932179,0.0009826726,0.003639191,0.00006526745,0.00001831794,0.00003964073,0.0005245415,0.00007596043,0.001436556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157215,"threshold_uncertainty_score":0.003871322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473319497672399,"score_gpt":0.2399148938410827,"score_spread":0.2251816988643588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}