{"id":"W2320379450","doi":"10.1161/circgenetics.113.000298","title":"iPS Cell–Derived Cardiogenicity is Hindered by Sustained Integration of Reprogramming Transgenes","year":2014,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Induced pluripotent stem cell; Reprogramming; Transgene; Biology; Cell biology; KLF4; Embryonic stem cell; Myosin; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009379362,0.0002623819,0.0004319285,0.0000986469,0.0001258054,0.00004145192,0.0002931076,0.0003119224,0.00001131546],"category_scores_gemma":[0.00009913309,0.000287024,0.0009344402,0.000251952,0.0001207377,0.000007868812,0.00008666063,0.0001207291,0.00000619135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004339718,"about_ca_system_score_gemma":0.0000859309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000034817,"about_ca_topic_score_gemma":0.00000463146,"domain_scores_codex":[0.9973438,0.0004149836,0.0004716923,0.0006940773,0.0006971593,0.0003782565],"domain_scores_gemma":[0.9980037,0.0000194017,0.0001376213,0.001210218,0.0004925298,0.0001365911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003093215,0.00004692621,0.002712521,0.00009829437,0.0005597329,9.901205e-7,0.0001512454,0.007920259,0.9633698,0.000005231655,0.0002659202,0.02483814],"study_design_scores_gemma":[0.001109371,0.0001117583,0.004702035,0.00001160162,0.000211893,0.000009446713,0.0001845518,0.004071951,0.9704849,0.00003832853,0.01873943,0.0003247058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7515488,0.007667628,0.2396753,0.00003043376,0.0001006696,0.0004896025,0.00002944745,0.00002148389,0.0004366108],"genre_scores_gemma":[0.9967401,0.0006566002,0.001693571,0.00004327951,0.0001832602,0.00003516792,0.0004757768,0.00005586156,0.0001163966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2451913,"threshold_uncertainty_score":0.9999582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473319497672399,"score_gpt":0.2399148938410827,"score_spread":0.2251816988643588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}