{"id":"W2320615728","doi":"10.1021/ac502600a","title":"Quantum Dot-Based Concentric FRET Configuration for the Parallel Detection of Protease Activity and Concentration","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Förster resonance energy transfer; Chemistry; Cyanine; Aptamer; Protease; Thrombin; Peptide; Alexa Fluor; Biophysics; Bioanalysis; Fluorescence; Nanotechnology; Quantum dot; Combinatorial chemistry; Biochemistry; Enzyme; Molecular biology; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001823768,0.00009716958,0.0001204907,0.000005168345,0.0000759333,0.00001533287,0.00005629608,0.0001232009,0.00000146727],"category_scores_gemma":[0.0002900273,0.00007056768,0.00007716624,0.00006170978,0.0001736641,0.000003413595,0.00001224549,0.00005988696,1.252242e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009823274,"about_ca_system_score_gemma":0.00003454242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000977184,"about_ca_topic_score_gemma":0.000003108493,"domain_scores_codex":[0.9994006,0.0000279233,0.0001573225,0.0002132627,0.00008656014,0.0001143053],"domain_scores_gemma":[0.9994516,0.00006846981,0.0001232061,0.0001899691,0.0001224111,0.00004438409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001606189,0.00002886617,0.0002283649,0.00003998414,0.0000287351,8.623766e-8,0.000001593993,0.00003020789,0.9957971,0.00007869994,0.00003911494,0.003566637],"study_design_scores_gemma":[0.0003554437,0.0001024057,0.0003795528,0.000007522745,0.00007586981,0.000001404069,0.000009528445,0.06585622,0.931495,0.0001038706,0.001525625,0.0000875496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7271272,0.00006963398,0.2721646,0.0002774449,0.00001115714,0.0002113922,0.00001271556,0.00001445453,0.0001114104],"genre_scores_gemma":[0.9992513,0.00002947352,0.0004123809,0.00007866847,0.00009556671,0.00001969894,0.00005408654,0.000006123163,0.00005267209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2721241,"threshold_uncertainty_score":0.2877666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101842227549819,"score_gpt":0.266720299695731,"score_spread":0.2565360769407491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}