{"id":"W2320627933","doi":"10.2147/ov.s66217","title":"High-throughput screening to enhance oncolytic virus immunotherapy","year":2016,"lang":"en","type":"review","venue":"Oncolytic Virotherapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Government of Canada; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Oncolytic virus; Vaccinia; Herpes simplex virus; Virus; Computational biology; Disease; Biology; CRISPR; Virology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.001167922,0.001462914,0.002583391,0.0004613042,0.0003295745,0.0001863252,0.002064185,0.001124997,0.001232535],"category_scores_gemma":[0.0000936424,0.001165345,0.001168242,0.0007427715,0.0002754187,0.00001795578,0.0003124395,0.0006641879,0.001766472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005356895,"about_ca_system_score_gemma":0.001448975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000887479,"about_ca_topic_score_gemma":0.0002030671,"domain_scores_codex":[0.9933325,0.0007817643,0.001366404,0.00208713,0.0009147897,0.001517417],"domain_scores_gemma":[0.995639,0.0001888073,0.0006028156,0.00284638,0.0001883133,0.0005347102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001488078,0.0001992715,5.577209e-7,0.0005248646,0.0008781817,0.00002433725,0.00004455217,0.000008057955,0.0443592,0.00001974111,0.004306859,0.9481463],"study_design_scores_gemma":[0.001287845,0.006181168,9.82806e-7,0.004082442,0.00009289415,0.00004024003,0.000006913716,0.000001689434,0.02424715,0.00005040251,0.9625878,0.001420515],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005527184,0.9844748,0.009152993,0.0002591082,0.0006066641,0.003908246,0.0003043551,0.0001142511,0.0006268314],"genre_scores_gemma":[0.00004543701,0.9783827,0.002566437,0.001766034,0.002532733,0.001658097,0.0002006961,0.0006722846,0.01217559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9582809,"threshold_uncertainty_score":0.9998121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03293868116363912,"score_gpt":0.3924652041768385,"score_spread":0.3595265230131994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}