{"id":"W2320670917","doi":"10.1101/pdb.prot080234","title":"High-Throughput RNAi Screening for Germline Apoptosis Genes in <i>Caenorhabditis elegans</i>","year":2014,"lang":"en","type":"article","venue":"Cold Spring Harbor Protocols","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Caenorhabditis elegans; RNA interference; Germline; Biology; Gene; Acridine orange; Phenotype; Mutant; Apoptosis; Genetics; Cell biology; Transgene; Genome; Computational biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005572032,0.0003168101,0.0003609453,0.00008386769,0.0001558612,0.0001017031,0.0004521564,0.000248546,0.00001319016],"category_scores_gemma":[0.0001562586,0.0003522364,0.0001463749,0.0001165035,0.00008036696,0.00001202517,0.0001820715,0.0001558097,0.000009491612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002948858,"about_ca_system_score_gemma":0.00006794378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001229766,"about_ca_topic_score_gemma":0.00008154046,"domain_scores_codex":[0.9979817,0.00008526629,0.0004596086,0.0006907379,0.0001995814,0.0005831411],"domain_scores_gemma":[0.9988147,0.00003457854,0.0001720364,0.0007033673,0.000139439,0.0001358626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009909904,0.0001350478,0.005290496,0.0001998622,0.00004244524,0.000001245831,0.00003716214,0.001390072,0.9884135,0.002062286,0.0006023853,0.00172639],"study_design_scores_gemma":[0.00184364,0.0004352924,0.004161753,0.0001045634,0.00001907639,6.947037e-7,0.000005255101,0.0006977636,0.826346,0.00008027642,0.1658769,0.0004287845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5530784,0.0002542587,0.40258,0.0004671315,0.0002924498,0.04308669,0.0000517405,0.0001043119,0.00008503914],"genre_scores_gemma":[0.8980394,0.00003753763,0.05261019,0.0006669539,0.001052535,0.04726509,0.00001851206,0.0001120346,0.0001977529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3499698,"threshold_uncertainty_score":0.999893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566498160861234,"score_gpt":0.2616488053469076,"score_spread":0.2459838237382952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}