{"id":"W2320834114","doi":"10.1158/1538-7445.am2013-4378","title":"Abstract 4378: Poly(ADP-ribose)glycohydrolase (PARG) is a novel therapeutic target in breast cancer.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Synthetic lethality; Poly ADP ribose polymerase; Cancer research; DNA repair; DNA damage; Olaparib; Cancer; PARP inhibitor; Biology; Breast cancer; Polymerase; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232504,0.0003787208,0.0003082458,0.0002200188,0.0001767352,0.0003662434,0.0003342588,0.0005977619,0.005498808],"category_scores_gemma":[0.00007856897,0.00009156059,0.0002160069,0.0002766813,0.0001705568,0.0002640356,0.0002400439,0.0007687811,0.002604975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003831139,"about_ca_system_score_gemma":0.0002624329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002583594,"about_ca_topic_score_gemma":0.0004718092,"domain_scores_codex":[0.9999437,0.000009500427,0.000002856732,0.00001228929,0.00001774846,0.00001382858],"domain_scores_gemma":[0.99997,0.000002924399,0.000007514607,0.00000250013,0.000003809315,0.00001333686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001621026,0.0007586306,0.001337824,0.001731111,0.00009351034,0.002239788,0.00007805768,0.0009131988,0.6091582,0.006430557,0.02771612,0.3479219],"study_design_scores_gemma":[0.0008170514,0.003113885,0.009096514,0.0001564229,0.0001666172,0.007930093,0.00005684728,0.001213592,0.3813055,0.002573297,0.5935411,0.00002923452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3986583,0.4651492,0.01653667,0.02206565,0.004281282,0.0004438215,0.002524319,0.001237392,0.08910336],"genre_scores_gemma":[0.7447948,0.1648438,0.01043642,0.004910845,0.001204438,0.0003373538,0.002651641,0.0001139585,0.07070671],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005498808,"threshold_uncertainty_score":0.0183953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1028217009173626,"score_gpt":0.4296681558549162,"score_spread":0.3268464549375536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}