{"id":"W2320840154","doi":"10.1021/jm401457n","title":"Design, Synthesis, and Structure–Activity Relationship Studies of a Potent PACE4 Inhibitor","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Peptide; Arginine; Residue (chemistry); Biochemistry; Structure–activity relationship; Leucine; Peptide synthesis; Stereochemistry; In vitro; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003309365,0.0004268393,0.0003889663,0.00030261,0.0001780544,0.0002760234,0.0003560189,0.0002565599,0.0007565045],"category_scores_gemma":[0.0002134764,0.0002121919,0.0002940435,0.0002499045,0.0001653227,0.0002610733,0.0001769833,0.0004965492,0.0002947277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003448037,"about_ca_system_score_gemma":0.0003544151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003581537,"about_ca_topic_score_gemma":0.0005157829,"domain_scores_codex":[0.9998627,0.00002842524,0.00001488153,0.00002729596,0.0000392859,0.00002734935],"domain_scores_gemma":[0.9999082,0.00001336269,0.00002676054,0.000007702496,0.00001718286,0.00002673249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002726915,0.0002225312,0.0001964692,0.0001049925,0.00002210566,0.0001819759,0.0000285489,0.002368227,0.9909707,0.0002723775,0.00007417094,0.005285194],"study_design_scores_gemma":[0.000239867,0.00393182,0.001077792,0.000007817122,0.0000668594,0.0005306397,0.00001424612,0.003084715,0.9853919,0.00007859278,0.005557631,0.00001821096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770939,0.004327831,0.01357691,0.0001571527,0.00004837297,0.0003583073,0.0004441202,0.00007225086,0.003921281],"genre_scores_gemma":[0.9757347,0.004049329,0.0164339,0.00009381399,0.00003627764,0.0001209855,0.0008018764,0.00002090751,0.002708226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007565045,"threshold_uncertainty_score":0.002530754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141607108843195,"score_gpt":0.2666776675357222,"score_spread":0.2452615964472902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}