{"id":"W2320840154","doi":"10.1021/jm401457n","title":"Design, Synthesis, and Structure–Activity Relationship Studies of a Potent PACE4 Inhibitor","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Peptide; Arginine; Residue (chemistry); Biochemistry; Structure–activity relationship; Leucine; Peptide synthesis; Stereochemistry; In vitro; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003044523,0.0001236683,0.0003278113,0.00002433902,0.00003853594,0.000008755804,0.0001033267,0.0001246412,0.0000449717],"category_scores_gemma":[0.001467267,0.00008729054,0.0001095122,0.0000621082,0.0001614017,0.000007646205,0.00004815931,0.0001624686,3.322912e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002151265,"about_ca_system_score_gemma":0.00005474774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005895303,"about_ca_topic_score_gemma":4.746094e-7,"domain_scores_codex":[0.9991089,0.0000496754,0.0003473205,0.0001331654,0.0002442721,0.0001166967],"domain_scores_gemma":[0.9988986,0.0001918345,0.0004023541,0.0001319817,0.0002556953,0.0001194808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000069092,0.00003983936,0.002776717,0.0001062532,0.0002098864,0.000003393297,0.00003434316,0.00001060159,0.9917161,5.720059e-7,0.001037519,0.003995673],"study_design_scores_gemma":[0.0002489676,0.00008509167,0.00301827,0.0001427449,0.0001636794,0.0001037198,0.0003329352,0.0000207852,0.9954628,0.000206141,0.0001273765,0.00008751042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941642,0.004542221,0.0005288142,0.0006168516,0.00002962945,0.00004117937,0.000003140346,0.00000143079,0.00007256514],"genre_scores_gemma":[0.9981167,0.0004864941,0.0009481122,0.00002788047,0.0003330605,0.000002615173,0.000001138781,0.000008116978,0.00007592137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004055727,"threshold_uncertainty_score":0.3559605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141607108843195,"score_gpt":0.2666776675357222,"score_spread":0.2452615964472902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}