{"id":"W2321043818","doi":"10.1021/bc100374p","title":"Ultrasmall Gold−Doxorubicin Conjugates Rapidly Kill Apoptosis-Resistant Cancer Cells","year":2010,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"HeLa; Doxorubicin; Chemistry; Apoptosis; Cytotoxicity; Cancer cell; Trypan blue; Cytotoxic T cell; Programmed cell death; TUNEL assay; Cytoplasm; Molecular biology; Cell culture; Cell biology; Cancer research; Cell; Biophysics; In vitro; Cancer; Biochemistry; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464458,0.0003512361,0.0002744288,0.0001893692,0.000111621,0.0002921681,0.0001452397,0.0003029289,0.0008765461],"category_scores_gemma":[0.0001809925,0.0001763571,0.00008746496,0.0001248426,0.0002319506,0.0002100669,0.0001436622,0.0003017862,0.0003279715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946682,"about_ca_system_score_gemma":0.0001499859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002913406,"about_ca_topic_score_gemma":0.0009115179,"domain_scores_codex":[0.9998614,0.00002477437,0.0000104813,0.00003038506,0.00004836479,0.00002455852],"domain_scores_gemma":[0.9999135,0.00002468554,0.00002149849,0.00001463057,0.00001105637,0.00001463374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002607862,0.00001019011,0.00006107637,0.00002169932,0.000002092769,0.00001684162,0.0000126399,0.00006759958,0.9983172,0.00007215736,0.00003887189,0.001353522],"study_design_scores_gemma":[0.000007811471,0.0001093179,0.0005304867,0.000001363611,0.000002663885,0.00008990756,0.000005106397,0.0004612077,0.9972868,0.00002583947,0.001477469,0.000002040749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917413,0.001673704,0.00454021,0.0001018881,0.00003069512,0.00002991677,0.0001180044,0.0001340329,0.001630232],"genre_scores_gemma":[0.9880154,0.0008779099,0.005492741,0.00006717743,0.00001083583,0.0000407893,0.000244362,0.00003560163,0.005215245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008765461,"threshold_uncertainty_score":0.00293231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009282056828115446,"score_gpt":0.2340072502448747,"score_spread":0.2247251934167592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}