{"id":"W2321043818","doi":"10.1021/bc100374p","title":"Ultrasmall Gold−Doxorubicin Conjugates Rapidly Kill Apoptosis-Resistant Cancer Cells","year":2010,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"HeLa; Doxorubicin; Chemistry; Apoptosis; Cytotoxicity; Cancer cell; Trypan blue; Cytotoxic T cell; Programmed cell death; TUNEL assay; Cytoplasm; Molecular biology; Cell culture; Cell biology; Cancer research; Cell; Biophysics; In vitro; Cancer; Biochemistry; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.001217483,0.001370866,0.001262853,0.0001126609,0.0004522286,0.0008308362,0.001892922,0.001095008,0.01367546],"category_scores_gemma":[0.0003289261,0.001378185,0.0005068426,0.0006358238,0.001573892,0.0005339911,0.000469452,0.001283453,0.003005023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740476,"about_ca_system_score_gemma":0.001121973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583979,"about_ca_topic_score_gemma":0.0001573208,"domain_scores_codex":[0.9923841,0.0001848639,0.001716486,0.002272647,0.001099988,0.002341941],"domain_scores_gemma":[0.9944722,0.0004697793,0.0009466784,0.002223897,0.000619364,0.001268094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005715546,0.0006032707,0.0002284327,0.001096015,0.0001235053,0.00006867347,0.0002915516,0.00005139251,0.9843573,0.00009597623,0.01211943,0.000392899],"study_design_scores_gemma":[0.00240703,0.0001217321,0.00008623893,0.0004097886,0.0003458652,0.00002014915,0.0003385628,0.0001891142,0.9704964,0.0001012672,0.02377941,0.001704456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843133,0.001874913,0.000007400635,0.001576714,0.005262725,0.0009875931,0.002078019,0.0004507399,0.003448587],"genre_scores_gemma":[0.987746,0.0007781239,0.000711825,0.0009548088,0.001947618,0.0002438283,0.00009679777,0.0002240795,0.007296933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01386092,"threshold_uncertainty_score":0.9999042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009282056828115446,"score_gpt":0.2340072502448747,"score_spread":0.2247251934167592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}