{"id":"W2321059112","doi":"10.1136/annrheumdis-2013-eular.2610","title":"AB0288 Safety, effectiveness, work and household productivity of anti-tnf alpha therapy with certolizumab pegol observed in adult rheumatoid arthritis patients in daily practice in canada: first interim analysis of the non-interventional fast can study","year":2013,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; University of Toronto; McMaster University","funders":"","keywords":"Medicine; Certolizumab pegol; Rheumatoid arthritis; Interim analysis; Bristol-Myers; Clinical endpoint; Internal medicine; Physical therapy; Concomitant; Interim; Adalimumab; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003699828,0.0006096509,0.001515912,0.0004241537,0.0006609534,0.001104445,0.0008735154,0.0008691148,0.001335791],"category_scores_gemma":[0.004335024,0.0004215751,0.001870272,0.001038201,0.000825206,0.0005900661,0.000371396,0.001441592,0.0002936238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005359367,"about_ca_system_score_gemma":0.007115616,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.2580096,"about_ca_topic_score_gemma":0.2421512,"domain_scores_codex":[0.9969477,0.0009935244,0.000149443,0.0003103746,0.0008537723,0.0007452081],"domain_scores_gemma":[0.9952909,0.0009370194,0.001425846,0.0004611115,0.001028527,0.0008566782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4571999,0.003896433,0.4887491,0.0002148364,0.004312266,0.000201694,0.0003036284,0.002155301,0.002363826,0.0001853285,0.002075595,0.03834204],"study_design_scores_gemma":[0.01514862,0.02743789,0.9524874,0.00003312612,0.002014932,0.00009255915,0.0001706687,0.00114868,0.0005657079,0.00006387383,0.0007952851,0.00004128947],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965115,0.0006308025,0.00007480391,0.00007772556,0.00001524659,0.0001195944,0.001621648,0.00001341016,0.0009352251],"genre_scores_gemma":[0.9972767,0.0001641204,0.00007861138,0.00008253037,0.00001839513,0.00005141541,0.001607983,0.000003296958,0.0007168903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7419904,"threshold_uncertainty_score":0.5130155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960749515947135,"score_gpt":0.2831767101394554,"score_spread":0.2535692149799841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}