{"id":"W2321078754","doi":"10.1021/acschembio.5b00761","title":"Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells <i>in Vivo</i>","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Congressionally Directed Medical Research Programs; National Cancer Institute; William Lawrence and Blanche Hughes Foundation; American Cancer Society","keywords":"Sphingosine-1-phosphate receptor; Receptor; In vivo; Pharmacology; Transporter; Biology; Cancer cell; Chemistry; Cancer research; Sphingosine-1-phosphate; Sphingosine; Biochemistry; Cell biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361316,0.0002881118,0.0004293299,0.0000533602,0.00003545443,0.0000177003,0.0001309369,0.000370105,0.000006543645],"category_scores_gemma":[0.00009334827,0.0002339772,0.00005392093,0.00009566385,0.0001828393,0.00001380361,0.0001293734,0.0001908186,0.000002152528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000361789,"about_ca_system_score_gemma":0.00004680294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002736293,"about_ca_topic_score_gemma":0.00004607769,"domain_scores_codex":[0.9985461,0.0001156281,0.0001809928,0.0006863025,0.00008270868,0.0003882393],"domain_scores_gemma":[0.99928,0.000121193,0.00008126241,0.0001979502,0.00005496099,0.0002646372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006449405,0.0001081816,0.004228228,0.00004347425,0.00004105105,0.00000175854,0.0003174847,0.000007938727,0.9924119,0.00001115961,0.0002344841,0.001949386],"study_design_scores_gemma":[0.002461019,0.0004357244,0.003197286,0.00005570296,0.00003104258,0.00000299918,0.00008047877,0.00001437751,0.9920413,0.00005814562,0.001339623,0.0002822225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971547,0.001141209,0.000680069,0.0001068384,0.0001939292,0.0005540999,0.0001170456,0.00001338157,0.00003874098],"genre_scores_gemma":[0.998257,0.0003558938,0.0003353035,0.0004959942,0.0002927957,0.0001645663,0.00005019198,0.0000222397,0.00002596214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001816079,"threshold_uncertainty_score":0.9541312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987693070984641,"score_gpt":0.2677787615377865,"score_spread":0.24790183082794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}