{"id":"W2321078754","doi":"10.1021/acschembio.5b00761","title":"Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells <i>in Vivo</i>","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Congressionally Directed Medical Research Programs; National Cancer Institute; William Lawrence and Blanche Hughes Foundation; American Cancer Society","keywords":"Sphingosine-1-phosphate receptor; Receptor; In vivo; Pharmacology; Transporter; Biology; Cancer cell; Chemistry; Cancer research; Sphingosine-1-phosphate; Sphingosine; Biochemistry; Cell biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008384119,0.0002475544,0.0001829544,0.00012483,0.0001207143,0.0001840546,0.0001898604,0.000226922,0.001551993],"category_scores_gemma":[0.00008551285,0.00006152686,0.0001295097,0.0000964031,0.0001644109,0.0002022125,0.00009787748,0.0003183793,0.0004205293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002476677,"about_ca_system_score_gemma":0.000142424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000375973,"about_ca_topic_score_gemma":0.0006411591,"domain_scores_codex":[0.9999534,0.000007354059,0.000003139357,0.00001193395,0.00001114107,0.00001316136],"domain_scores_gemma":[0.999962,0.000007209763,0.00001441735,0.00000428447,0.000004021591,0.000008001528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001741573,0.00002194613,0.0001204712,0.00007645707,0.000004521736,0.0001319247,0.00001450825,0.000148818,0.9864659,0.0007950553,0.0001756559,0.01187059],"study_design_scores_gemma":[0.00003121692,0.0008004488,0.0009695883,0.000006708799,0.00001569898,0.0007319576,0.00001437484,0.0003823248,0.9800821,0.0001325293,0.01682488,0.000008254294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9382501,0.02456081,0.01805303,0.0005595645,0.00021371,0.0001023354,0.0006610841,0.0003322072,0.01726712],"genre_scores_gemma":[0.9768759,0.008439139,0.009149834,0.0001574718,0.00006428945,0.000041201,0.000320568,0.0000339033,0.004917674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551993,"threshold_uncertainty_score":0.005191922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987693070984641,"score_gpt":0.2677787615377865,"score_spread":0.24790183082794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}