{"id":"W2321118242","doi":"10.1093/neuonc/nou206.51","title":"SINGLE CELL DERIVED CLONAL ANALYSIS OF HUMAN GLIOBLASTOMA LINKS FUNCTIONAL AND GENOMIC HETEROGENEITY","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Temozolomide; clone (Java method); Biology; Autocrine signalling; Cancer research; Paracrine signalling; Glioblastoma; Genetics; Gene; Somatic evolution in cancer; Drug resistance; Computational biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125875,0.0001060299,0.0001930795,0.000524178,0.0001750378,0.0002239043,0.0001486239,0.0002016151,0.0008181675],"category_scores_gemma":[0.0002940306,0.00008334283,0.0001463553,0.0002965913,0.0001179066,0.00009022807,0.0001725197,0.0002167473,0.0002728806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916576,"about_ca_system_score_gemma":0.0001339069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009565627,"about_ca_topic_score_gemma":0.001860327,"domain_scores_codex":[0.9998983,0.00001367423,0.000009688679,0.00002479519,0.00003633277,0.00001714168],"domain_scores_gemma":[0.9997904,0.00006296026,0.00002150037,0.0000318789,0.00007188326,0.00002151602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190449,0.00005452524,0.01310675,0.00004377755,0.00002219595,0.0001598343,0.00008791871,0.0002646043,0.9763713,0.0001568108,0.0001793223,0.009362567],"study_design_scores_gemma":[0.00004391525,0.0011186,0.1943826,0.00001803561,0.0001761873,0.003116732,0.0001878744,0.007135358,0.788933,0.0003905145,0.004477737,0.00001946944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914596,0.0006792488,0.006039098,0.00004138208,0.00000987538,0.0000971105,0.0007982294,0.00006306133,0.0008122961],"genre_scores_gemma":[0.9919958,0.0004272031,0.004982911,0.00004505982,0.000008649464,0.0001069858,0.001737749,0.00001952124,0.0006761678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009565627,"threshold_uncertainty_score":0.002737045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02460563989939834,"score_gpt":0.2779543514618333,"score_spread":0.2533487115624349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}