{"id":"W2321118242","doi":"10.1093/neuonc/nou206.51","title":"SINGLE CELL DERIVED CLONAL ANALYSIS OF HUMAN GLIOBLASTOMA LINKS FUNCTIONAL AND GENOMIC HETEROGENEITY","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Temozolomide; clone (Java method); Biology; Autocrine signalling; Cancer research; Paracrine signalling; Glioblastoma; Genetics; Gene; Somatic evolution in cancer; Drug resistance; Computational biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071548,0.0001423097,0.0005363195,0.0002949437,0.0000771307,0.000007087694,0.00004673603,0.000193828,0.0001642389],"category_scores_gemma":[0.00003678758,0.0001257259,0.0001864864,0.0002181609,0.0001255593,0.00002041462,0.00006349044,0.0001647933,0.00001202204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009833484,"about_ca_system_score_gemma":0.00004605458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000023847,"about_ca_topic_score_gemma":0.0002163894,"domain_scores_codex":[0.9989275,0.0001222891,0.0002890585,0.0003306561,0.0001407889,0.0001897543],"domain_scores_gemma":[0.9991165,0.0002743882,0.0001581898,0.0002222684,0.00007972681,0.0001489158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001541604,0.0009233265,0.1261051,0.00001492425,0.000396377,0.00004207641,0.00005384513,0.00007182652,0.8690214,0.00005062279,0.0001874426,0.002978904],"study_design_scores_gemma":[0.00314375,0.00499512,0.5173811,0.000004425217,0.002214108,0.00005707729,0.00001755006,0.0007833018,0.4640992,0.00002684558,0.007177382,0.0001001455],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981658,0.0001299885,0.0000525267,0.00047611,0.0001242514,0.0001524767,0.00001311915,0.00002399051,0.0008617346],"genre_scores_gemma":[0.9987421,0.00001636561,0.0001850985,0.0008575802,0.0001111131,0.00002098481,0.00004545534,0.00001506985,0.000006211825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4049222,"threshold_uncertainty_score":0.5126955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02460563989939834,"score_gpt":0.2779543514618333,"score_spread":0.2533487115624349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}