{"id":"W2321214963","doi":"10.1093/jnen/nlw017","title":"Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium","year":2016,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; International Collaboration On Repair Discoveries; Vancouver Coastal Health","funders":"Medical Research Council","keywords":"Choroid plexus; Immunoglobulin D; Basement membrane; Immunology; Stromal cell; Biology; Complement system; Humoral immunity; Antibody; Pathology; Acquired immune system; Cerebrospinal fluid; Epithelium; Immune system; Cell biology; Central nervous system; Medicine; B cell; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429369,0.0002812666,0.0001235662,0.0008321489,0.0002931891,0.0004250908,0.0001607883,0.0003178483,0.001068935],"category_scores_gemma":[0.0001435628,0.0001229412,0.0001201839,0.0002875863,0.0006381992,0.0005137395,0.0002474727,0.0002783598,0.0001733622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004728001,"about_ca_system_score_gemma":0.0004497182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003890921,"about_ca_topic_score_gemma":0.003260303,"domain_scores_codex":[0.9999211,0.00002611919,0.000005930075,0.0000135435,0.00001492918,0.00001836306],"domain_scores_gemma":[0.9999483,0.000009825932,0.00001136039,0.000005115065,0.00001103959,0.00001441928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001457961,0.00005846891,0.01219096,0.0006161192,0.00004516375,0.002679216,0.0004884104,0.0001905569,0.945523,0.00328137,0.0004991325,0.03296958],"study_design_scores_gemma":[0.0002874484,0.00177031,0.3290102,0.0004290926,0.0002952988,0.02016303,0.002494293,0.003475129,0.5883979,0.008750282,0.04481598,0.0001110466],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9051715,0.08252549,0.002956097,0.0007937272,0.00005931245,0.00004429842,0.0001603629,0.0000641395,0.008225053],"genre_scores_gemma":[0.9810191,0.01344954,0.002401824,0.0001082769,0.00003626396,0.00002294021,0.000073086,0.000005919252,0.002883017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003890921,"threshold_uncertainty_score":0.007736564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0302233874295128,"score_gpt":0.2929931120483303,"score_spread":0.2627697246188175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}