{"id":"W2321318692","doi":"10.1093/neuonc/nou278.5","title":"TM-05 * PTEN INDUCED KINASE1 (PINK1) NEGATIVELY REGULATES AEROBIC GLYCOLYSIS IN GLIOBLASTOMA","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Occupational Cancer Research Centre; Hospital for Sick Children","funders":"","keywords":"PINK1; Warburg effect; Anaerobic glycolysis; PTEN; Glycolysis; Cell biology; Biology; Cancer research; Kinase; Reprogramming; Cancer cell; Chemistry; Signal transduction; Cell; Apoptosis; Biochemistry; Mitophagy; PI3K/AKT/mTOR pathway; Cancer; Autophagy; Metabolism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006483566,0.000200926,0.0001541908,0.0002235517,0.0001549064,0.0002569344,0.0001410424,0.0001206466,0.001213284],"category_scores_gemma":[0.0000644344,0.00008087997,0.0001204101,0.0001789541,0.0001769679,0.0001314386,0.0001362993,0.0003472208,0.0003381431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003535179,"about_ca_system_score_gemma":0.0002744173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001306056,"about_ca_topic_score_gemma":0.001562942,"domain_scores_codex":[0.9999405,0.000007179241,0.000004762725,0.000008949753,0.00001766912,0.00002090688],"domain_scores_gemma":[0.9999651,0.000003030754,0.00001112337,0.000002155496,0.000003217197,0.00001549054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002176456,0.00004518614,0.0005282117,0.00003373432,0.000004973669,0.00009794435,0.00001107678,0.0001525102,0.9963014,0.0002223569,0.0002076932,0.002177228],"study_design_scores_gemma":[0.00003055461,0.0003631356,0.01293546,0.000007041298,0.00002425839,0.0005361803,0.00004842029,0.002101533,0.9802245,0.0001738178,0.003550852,0.000004106323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954065,0.001172676,0.001077175,0.0002218927,0.00002820597,0.00001146935,0.0003813792,0.0001030624,0.00159757],"genre_scores_gemma":[0.9966413,0.000649282,0.0004635583,0.00005157263,0.000003839648,0.00001190035,0.0003809597,0.000011222,0.001786443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306056,"threshold_uncertainty_score":0.004058838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01123747077533289,"score_gpt":0.2594906644635961,"score_spread":0.2482531936882633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}