{"id":"W2321350289","doi":"10.1158/1538-7445.am10-2680","title":"Abstract 2680: Nonautoinhibitory properties of the C-terminal helix of the mitogen- and stress-activated protein kinase 1","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Light Source (Canada)","funders":"","keywords":"Autophosphorylation; Mitogen-activated protein kinase kinase; MAP2K7; Cyclin-dependent kinase 9; c-Raf; MAP kinase kinase kinase; Protein kinase A; Cyclin-dependent kinase 2; MAPK14; Protein kinase domain; Protein kinase R; Chemistry; Kinase; Cell biology; Biochemistry; Molecular biology; Biology; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009439535,0.0006931822,0.0002746887,0.0001353219,0.0001844452,0.00025575,0.0004122898,0.0002431278,0.004499691],"category_scores_gemma":[0.0001750806,0.0001427783,0.000229492,0.0001262627,0.0002106036,0.0001445311,0.0001575659,0.0004679628,0.0023246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377778,"about_ca_system_score_gemma":0.0001949192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005948058,"about_ca_topic_score_gemma":0.0003727622,"domain_scores_codex":[0.9999216,0.00001008664,0.000005199844,0.00001654997,0.00003257508,0.00001398404],"domain_scores_gemma":[0.9998484,0.00002389031,0.00003960705,0.000008972625,0.00002402704,0.00005507749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007035832,0.00007015634,0.00047302,0.0001633611,0.00001867083,0.0003934313,0.00001771408,0.000438583,0.9940134,0.0003998158,0.0006430541,0.002665233],"study_design_scores_gemma":[0.0004735099,0.0008139026,0.01826013,0.00005526578,0.0000571451,0.003306387,0.00006449841,0.007357083,0.9410088,0.0008497491,0.02769699,0.00005663867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982887,0.004376592,0.003628969,0.0002656126,0.0002210917,0.00006796807,0.001259449,0.0002246773,0.007068718],"genre_scores_gemma":[0.9820932,0.001221517,0.003085234,0.000134643,0.0001091095,0.00006538307,0.005433223,0.00005378952,0.007803878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004499691,"threshold_uncertainty_score":0.01505303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0380924380102597,"score_gpt":0.3056193643084202,"score_spread":0.2675269262981606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}