{"id":"W2321436947","doi":"10.1021/bi3012719","title":"Mutagenesis of a Conserved Glutamate Reveals the Contribution of Electrostatic Energy to Adenosylcobalamin Co–C Bond Homolysis in Ornithine 4,5-Aminomutase and Methylmalonyl-CoA Mutase","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Homolysis; Adenosylcobalamin; Mutase; Chemistry; Stereochemistry; Enzyme kinetics; Active site; Cofactor; Enzyme; Biochemistry; Radical","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604743,0.000423278,0.0001711704,0.000127294,0.0001246906,0.0002307647,0.000266485,0.0003317015,0.0006447631],"category_scores_gemma":[0.0002430031,0.0001349874,0.0002883105,0.0001617971,0.0002204859,0.0001032572,0.0002392086,0.0003189977,0.0002407156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004039216,"about_ca_system_score_gemma":0.0002102336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001546883,"about_ca_topic_score_gemma":0.001355897,"domain_scores_codex":[0.999838,0.00004115663,0.00002318443,0.00002528251,0.00004272346,0.00002960723],"domain_scores_gemma":[0.9998614,0.00003327606,0.0000455137,0.00001124959,0.00001778264,0.00003080369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002715791,0.0000569454,0.001009194,0.00002040245,0.00001580505,0.0002674449,0.00003033308,0.0004190252,0.9965412,0.000138366,0.00001855382,0.001211076],"study_design_scores_gemma":[0.0000457768,0.000524977,0.008352669,0.00001017275,0.00003080791,0.0008830646,0.00007009894,0.003794151,0.9854719,0.00006413957,0.0007378607,0.00001428278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999223,0.00004435454,0.0004877355,0.00001507551,0.00000324564,0.000007873922,0.00004651144,0.000007291486,0.0001649781],"genre_scores_gemma":[0.9989069,0.00004699814,0.0006790182,0.00001278778,0.000001398138,0.00000563293,0.00009007585,0.000009049013,0.0002481201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001546883,"threshold_uncertainty_score":0.003075719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003547308694439092,"score_gpt":0.2213175868675815,"score_spread":0.2177702781731424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}