{"id":"W2321436947","doi":"10.1021/bi3012719","title":"Mutagenesis of a Conserved Glutamate Reveals the Contribution of Electrostatic Energy to Adenosylcobalamin Co–C Bond Homolysis in Ornithine 4,5-Aminomutase and Methylmalonyl-CoA Mutase","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Homolysis; Adenosylcobalamin; Mutase; Chemistry; Stereochemistry; Enzyme kinetics; Active site; Cofactor; Enzyme; Biochemistry; Radical","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102092,0.0002182516,0.0003611247,0.00006382537,0.00004280342,0.00001718455,0.0002264683,0.000171299,0.0000328162],"category_scores_gemma":[0.0004175266,0.0001805263,0.0000931321,0.0002534801,0.0002039144,0.000006437436,0.0001050356,0.00006567581,0.000002335027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001300085,"about_ca_system_score_gemma":0.00009757283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326356,"about_ca_topic_score_gemma":0.00005140603,"domain_scores_codex":[0.9986072,0.00009875729,0.0004754304,0.0003581166,0.0001587542,0.0003017301],"domain_scores_gemma":[0.9989631,0.00005988767,0.0002317964,0.0004607278,0.0001634996,0.0001210094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153406,0.0001033507,0.006602767,0.00006943221,0.00006310843,0.000003570256,0.00005033653,0.000006751826,0.9909617,0.00004281642,0.001296961,0.0006838524],"study_design_scores_gemma":[0.0009661602,0.0001005745,0.01014941,0.00002729483,0.00006134756,0.00001581817,0.0002586748,0.00003029473,0.9877259,0.0001432868,0.0003278693,0.0001934162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937704,0.005211182,0.0002308345,0.0002021916,0.00001921444,0.0002554726,0.0002147376,0.000006024846,0.00008993284],"genre_scores_gemma":[0.9983942,0.0003526281,0.0003316658,0.0002804304,0.00002863259,0.00009784975,0.0003507034,0.00001700055,0.0001469138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004858554,"threshold_uncertainty_score":0.7361647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003547308694439092,"score_gpt":0.2213175868675815,"score_spread":0.2177702781731424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}