{"id":"W2321452140","doi":"10.1021/jo501242r","title":"Shifting the Energy Landscape of Multicomponent Reactions Using Aziridine Aldehyde Dimers: A Mechanistic Study","year":2014,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Isocyanide; Aziridine; Aldehyde; Iminium; Ugi reaction; Dimer; Stereoselectivity; Reactivity (psychology); Stereochemistry; Combinatorial chemistry; Organic chemistry; Catalysis; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003122605,0.0006522947,0.0005262234,0.0003098075,0.0003500399,0.0005203469,0.0007949315,0.0004545126,0.003770232],"category_scores_gemma":[0.0004000974,0.0003507061,0.0004107752,0.0002175998,0.0004287339,0.0009189638,0.0004528128,0.0008346106,0.0004224034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006102223,"about_ca_system_score_gemma":0.0003720215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007752004,"about_ca_topic_score_gemma":0.001287461,"domain_scores_codex":[0.9998858,0.00001091412,0.000004032457,0.00003099457,0.0000307745,0.00003745947],"domain_scores_gemma":[0.9998752,0.00006135098,0.0000187004,0.00001222128,0.00001551404,0.00001706045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001058026,0.0008394668,0.004157071,0.001018357,0.0001965051,0.002101206,0.0004627788,0.1940535,0.7184526,0.04291477,0.0008240473,0.03392167],"study_design_scores_gemma":[0.000157068,0.001259104,0.004859805,0.00003601121,0.0001186734,0.0005780602,0.0004091353,0.6965335,0.2797594,0.01265749,0.003545203,0.00008666068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796385,0.0008167733,0.01356057,0.0001427338,0.00002760283,0.00005411572,0.00008557923,0.00009004389,0.005583997],"genre_scores_gemma":[0.995376,0.0005623227,0.002866422,0.00002542754,0.000003643041,0.00003900584,0.00007510654,0.000018959,0.001032997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003770232,"threshold_uncertainty_score":0.0126127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008943310697915,"score_gpt":0.2304642048342446,"score_spread":0.2203747717272654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}