{"id":"W2321492301","doi":"10.1074/jbc.m114.615112","title":"Src Homology 2 Domain Containing Protein 5 (SH2D5) Binds the Breakpoint Cluster Region Protein, BCR, and Regulates Levels of Rac1-GTP","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Signal transducing adaptor protein; SH2 domain; Biology; Proto-oncogene tyrosine-protein kinase Src; Phosphotyrosine-binding domain; Cell biology; Amphiphysin; PDZ domain; GRB2; Small GTPase; SH3 domain; Proximity ligation assay; Plasma protein binding; breakpoint cluster region; RAC1; Molecular biology; Guanine nucleotide exchange factor; Pleckstrin homology domain; Signal transduction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006124178,0.000401052,0.0001425732,0.0002742556,0.0002290531,0.0002682869,0.0002200398,0.0003136407,0.001796641],"category_scores_gemma":[0.00006044417,0.0001287053,0.0002765254,0.0001657281,0.000125529,0.0001426346,0.0003487151,0.0002637865,0.0006185943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005203838,"about_ca_system_score_gemma":0.0001173982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258014,"about_ca_topic_score_gemma":0.00229277,"domain_scores_codex":[0.9999014,0.00000696822,0.000005193218,0.00003037319,0.00002765985,0.00002832345],"domain_scores_gemma":[0.9999691,0.000002436758,0.00001159707,0.000002145048,0.000002874394,0.00001192285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009546115,0.00001484642,0.0025246,0.00005691055,0.00001817476,0.0002078369,0.00001724535,0.0001069984,0.994172,0.0001711554,0.0002514685,0.00236335],"study_design_scores_gemma":[0.000033521,0.0002916204,0.09923575,0.0000232046,0.00005549443,0.002047797,0.0001301847,0.003120014,0.8684554,0.0001401467,0.02645394,0.00001286078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898239,0.003343417,0.003399464,0.0001197762,0.00003151104,0.00001648992,0.001150816,0.00008051217,0.002034144],"genre_scores_gemma":[0.9919641,0.0007146794,0.001278779,0.00007085109,0.00000645824,0.00001119363,0.002044723,0.000007182282,0.003902075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001796641,"threshold_uncertainty_score":0.006010354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208318177806645,"score_gpt":0.2841516989073666,"score_spread":0.2520685171293002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}