{"id":"W2321492301","doi":"10.1074/jbc.m114.615112","title":"Src Homology 2 Domain Containing Protein 5 (SH2D5) Binds the Breakpoint Cluster Region Protein, BCR, and Regulates Levels of Rac1-GTP","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Signal transducing adaptor protein; SH2 domain; Biology; Proto-oncogene tyrosine-protein kinase Src; Phosphotyrosine-binding domain; Cell biology; Amphiphysin; PDZ domain; GRB2; Small GTPase; SH3 domain; Proximity ligation assay; Plasma protein binding; breakpoint cluster region; RAC1; Molecular biology; Guanine nucleotide exchange factor; Pleckstrin homology domain; Signal transduction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001414306,0.0001737962,0.0005450271,0.00005009589,0.00007113314,0.00001783796,0.000236875,0.0003247164,0.0001635479],"category_scores_gemma":[0.001385423,0.00008931399,0.0001719994,0.0001273199,0.000572354,0.00003142868,0.0001808194,0.0007193338,0.000002333149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005718238,"about_ca_system_score_gemma":0.00009572545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004134726,"about_ca_topic_score_gemma":2.863941e-7,"domain_scores_codex":[0.9982301,0.0002588133,0.0006586691,0.000222925,0.0003359405,0.0002935541],"domain_scores_gemma":[0.9983903,0.0002903389,0.0005216054,0.0002796182,0.0003204325,0.0001976584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001286622,0.0001039907,0.001442671,0.0001569245,0.00005469794,0.000119869,0.00006157305,0.000001331586,0.9925908,0.00005132336,0.0001519302,0.003978259],"study_design_scores_gemma":[0.002636461,0.002030342,0.01094703,0.0004475387,0.00002941979,0.003124902,0.0002778579,0.00006807561,0.9748762,0.002697882,0.002725858,0.0001384261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992571,0.0004309643,0.0005143366,0.005059341,0.00001548708,0.0003556832,0.000002001659,0.000009406768,0.00104178],"genre_scores_gemma":[0.9975478,0.00003354234,0.001166757,0.0002109954,0.0002369483,0.00001182966,0.000002423867,0.00001252503,0.0007771912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0177146,"threshold_uncertainty_score":0.3642119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208318177806645,"score_gpt":0.2841516989073666,"score_spread":0.2520685171293002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}