{"id":"W2321676231","doi":"10.1158/1538-7445.am2011-lb-109","title":"Abstract LB-109: BCR-ABL1 kinase activity but not its expression is dispensable for Ph+ quiescent stem cell survival which depends on the PP2A-controlled Jak2 activation and is sensitive to FTY720 treatment","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Protein phosphatase 2; Progenitor cell; Stem cell; Cancer research; CD38; Haematopoiesis; Biology; Tyrosine kinase; CD34; Cell biology; Signal transduction; Phosphatase; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001828617,0.0003884842,0.0007010709,0.0002813978,0.0005585219,0.0001167138,0.0002653635,0.0002302109,0.0006907936],"category_scores_gemma":[0.000356416,0.0002465648,0.0001654732,0.0004991255,0.0001483493,0.0002102301,0.000232091,0.0006098035,0.00011535],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01295899,"about_ca_system_score_gemma":0.004442737,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006663817,"about_ca_topic_score_gemma":0.0005225519,"domain_scores_codex":[0.995442,0.0004012104,0.0003535687,0.000987085,0.001641294,0.001174834],"domain_scores_gemma":[0.9954176,0.002024395,0.0001239115,0.0008838195,0.0009691707,0.0005811013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05387226,0.001015461,0.0001136703,0.0004706731,0.0002893314,0.00008102231,0.006824226,0.00001742551,0.9149392,0.00008429307,0.005542108,0.01675033],"study_design_scores_gemma":[0.02616197,0.001546059,0.002217351,0.0004574945,0.0000571842,0.000004766776,0.001629628,0.001827551,0.9644901,0.00001092959,0.00136367,0.0002332669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857934,0.00009974975,0.00006719237,0.003924679,0.0001585325,0.005532971,0.0001843,0.00003778663,0.004201364],"genre_scores_gemma":[0.986548,0.0004380066,0.00003403089,0.0003608234,0.0003382466,0.001770218,0.00001328852,0.00008108868,0.01041628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04955093,"threshold_uncertainty_score":0.9999987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1732341784058122,"score_gpt":0.3960053296568782,"score_spread":0.222771151251066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}