{"id":"W2321676231","doi":"10.1158/1538-7445.am2011-lb-109","title":"Abstract LB-109: BCR-ABL1 kinase activity but not its expression is dispensable for Ph+ quiescent stem cell survival which depends on the PP2A-controlled Jak2 activation and is sensitive to FTY720 treatment","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Protein phosphatase 2; Progenitor cell; Stem cell; Cancer research; CD38; Haematopoiesis; Biology; Tyrosine kinase; CD34; Cell biology; Signal transduction; Phosphatase; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007939497,0.0002085241,0.0001719781,0.0001431113,0.0001346113,0.0002684025,0.0001702864,0.0001628457,0.003854102],"category_scores_gemma":[0.00006093234,0.00009196872,0.0001148314,0.0001219248,0.0001836595,0.0001271822,0.000140804,0.0005064235,0.001007683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314285,"about_ca_system_score_gemma":0.0001187052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006301446,"about_ca_topic_score_gemma":0.0005577059,"domain_scores_codex":[0.9998723,0.00001657729,0.0000134511,0.00002423725,0.00004450119,0.00002887034],"domain_scores_gemma":[0.9999111,0.00001688441,0.00002180879,0.00001271038,0.000007443242,0.00003017479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006264031,0.00001874271,0.00008646992,0.00001323405,0.000001560553,0.00003226944,0.000005554343,0.00001303139,0.9992687,0.00005421449,0.0000609508,0.0003826909],"study_design_scores_gemma":[0.00001939623,0.0001834349,0.005697345,0.0000063187,0.000008296742,0.0003796563,0.00002062513,0.0005217221,0.9891524,0.00004387884,0.003964337,0.000002660461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919462,0.001286973,0.001717727,0.0001382816,0.00003365894,0.00002907577,0.00160326,0.000175903,0.003068924],"genre_scores_gemma":[0.991013,0.0003596308,0.0007716709,0.00007468538,0.00001312684,0.00003737403,0.002889111,0.00003430824,0.004807168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003854102,"threshold_uncertainty_score":0.01289326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1732341784058122,"score_gpt":0.3960053296568782,"score_spread":0.222771151251066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}