{"id":"W2321722406","doi":"10.1093/jnen/62.11.1192","title":"Epigenetic Silencing of the<i>HIC-1</i>Gene in Human Medulloblastomas","year":2003,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Montreal Children's Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"CpG site; Methylation; Exon; DNA methylation; Gene silencing; Biology; Epigenetics; Genetics; Gene; Coding region; Molecular biology; Cancer research; Demethylating agent; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006021237,0.0001766683,0.0003114838,0.0001354397,0.00006418998,0.000004832354,0.0003242552,0.0001818659,0.00001314836],"category_scores_gemma":[0.0002301398,0.0001479011,0.0001768952,0.0001459429,0.0002510375,0.000005241298,0.0001119237,0.0002961317,8.582744e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001196029,"about_ca_system_score_gemma":0.00007338751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004092711,"about_ca_topic_score_gemma":0.00001361527,"domain_scores_codex":[0.9977632,0.0007524107,0.0007591263,0.0002659794,0.0001670345,0.0002922927],"domain_scores_gemma":[0.9988875,0.00004768855,0.0005740459,0.0003270398,0.00008826611,0.0000754522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001138953,0.0001979854,0.04572454,0.000003681475,0.000009102229,0.0001081298,0.0001102429,0.0005837121,0.952989,0.00008583249,0.0000100502,0.00006386954],"study_design_scores_gemma":[0.0008356386,0.002314815,0.06357157,0.000005588167,0.00001135813,0.0006209394,0.00004871977,0.000003469734,0.9316925,0.0001600338,0.000639087,0.00009631151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956448,0.00287252,0.0001948899,0.00007690476,0.0007760707,0.0001244428,0.000001765044,0.000002076808,0.0003065318],"genre_scores_gemma":[0.9991094,0.0001244231,0.0002759178,0.0003335406,0.00009926082,0.000002978289,0.000001201129,0.00002818128,0.00002502323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0212965,"threshold_uncertainty_score":0.6031232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009364825299746792,"score_gpt":0.259474561607727,"score_spread":0.2501097363079802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}