{"id":"W2321776593","doi":"10.1021/bi400693w","title":"Dihydrodipicolinate Synthase from <i>Campylobacter jejuni</i>: Kinetic Mechanism of Cooperative Allosteric Inhibition and Inhibitor-Induced Substrate Cooperativity","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Allosteric regulation; Cooperativity; Cooperative binding; Lysine; Allosteric enzyme; Chemistry; Enzyme; Stereochemistry; Substrate (aquarium); Enzyme kinetics; Binding site; Uncompetitive inhibitor; Biochemistry; Active site; Amino acid; Biology; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001014207,0.0002388536,0.0002709455,0.00002885483,0.0000988516,0.0001115686,0.00009159822,0.0001991219,0.0009303001],"category_scores_gemma":[0.00005980497,0.0002075569,0.00003880004,0.000120103,0.0001279405,0.0002689421,0.00008857423,0.0001344719,0.00005745016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003218415,"about_ca_system_score_gemma":0.00005155545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002357685,"about_ca_topic_score_gemma":0.00001706615,"domain_scores_codex":[0.9987493,0.00006888708,0.0003199069,0.0004456281,0.0001887928,0.0002275016],"domain_scores_gemma":[0.9991901,0.00005128288,0.0001605496,0.0002842777,0.0001912049,0.0001225816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003424191,0.00005875245,0.00006589245,0.00004392939,0.00001033344,0.000004652821,0.0001194399,0.00000208655,0.9992049,0.0001003404,0.0001720312,0.0001834538],"study_design_scores_gemma":[0.0005385926,0.0001235018,0.001180007,0.00007390834,0.00002682506,0.00001219658,0.00009459348,0.0001388635,0.9971492,0.0004257421,0.00001156149,0.0002250225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982936,0.00008155685,0.0001529147,0.00008520562,0.0002719827,0.000262302,0.0001247216,0.00005261229,0.0006751138],"genre_scores_gemma":[0.9991188,0.00001280161,0.0003181824,0.0001155396,0.0001923858,0.00004118652,0.00008501646,0.00001716097,0.00009893491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205566,"threshold_uncertainty_score":0.999983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008874171521643636,"score_gpt":0.205884518815437,"score_spread":0.1970103472937934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}