{"id":"W2321776593","doi":"10.1021/bi400693w","title":"Dihydrodipicolinate Synthase from <i>Campylobacter jejuni</i>: Kinetic Mechanism of Cooperative Allosteric Inhibition and Inhibitor-Induced Substrate Cooperativity","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Allosteric regulation; Cooperativity; Cooperative binding; Lysine; Allosteric enzyme; Chemistry; Enzyme; Stereochemistry; Substrate (aquarium); Enzyme kinetics; Binding site; Uncompetitive inhibitor; Biochemistry; Active site; Amino acid; Biology; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002421481,0.0003342432,0.0004160588,0.0001268261,0.00009484668,0.0003648395,0.0004309218,0.0003022297,0.0003753978],"category_scores_gemma":[0.0003539378,0.0002057815,0.0002891865,0.0001421153,0.0003019877,0.0002767369,0.0001615595,0.0003744353,0.0001629978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009879901,"about_ca_system_score_gemma":0.0003745969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003639025,"about_ca_topic_score_gemma":0.002556878,"domain_scores_codex":[0.9998398,0.00002853159,0.00001454818,0.00004824977,0.00003223573,0.00003669256],"domain_scores_gemma":[0.9998361,0.00004705124,0.0000493206,0.00001362766,0.00002828465,0.00002562917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002247171,0.00005018312,0.002226785,0.0001276472,0.0000172544,0.00008294283,0.00005042221,0.002657447,0.990518,0.0002848463,0.00006321034,0.003696528],"study_design_scores_gemma":[0.0000313189,0.0002761661,0.01291365,0.000009838636,0.00003122022,0.0003477978,0.00006485078,0.04736349,0.9374268,0.0002987691,0.001200579,0.00003561312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912146,0.0007567767,0.006792604,0.0001514153,0.000008694469,0.00002103573,0.0000811901,0.00007434927,0.0008991537],"genre_scores_gemma":[0.9970795,0.0002081207,0.002222068,0.00002129344,0.000001704253,0.000009024916,0.0001039896,0.000009951314,0.0003442846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003639025,"threshold_uncertainty_score":0.007235646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008874171521643636,"score_gpt":0.205884518815437,"score_spread":0.1970103472937934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}