{"id":"W2322061949","doi":"10.1093/neuonc/nou242.8","title":"CS-08 * SONIC HEDGEHOG SIGNALING PROTECTS ATOH1 FROM DEGRADATION MEDIATED BY THE HECT DOMAIN E3 UBIQUITIN LIGASE HUWE1 IN CEREBELLAR GRANULE NEURON PROGENITORS","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Ubiquitin ligase; Sonic hedgehog; Transcription factor; Cell biology; Biology; GLI2; Cerebellum; Ubiquitin; Molecular biology; Genetics; Signal transduction; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008989381,0.0004303139,0.0004932021,0.000100584,0.000297165,0.00004511182,0.0005273765,0.0004733565,0.00001952062],"category_scores_gemma":[0.001150227,0.0003619707,0.0001535028,0.0003135316,0.0002719531,0.00001035869,0.000271285,0.0005399037,0.00005594745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052835,"about_ca_system_score_gemma":0.000254253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001767762,"about_ca_topic_score_gemma":0.0004709469,"domain_scores_codex":[0.9959021,0.001529201,0.0006215571,0.0009379318,0.000287892,0.0007212826],"domain_scores_gemma":[0.9983017,0.0005128738,0.000324401,0.0005854846,0.0001151472,0.0001604067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001940981,0.0001575359,0.001598776,0.00002211676,0.00004822311,0.00003126936,0.000337578,0.00009530443,0.9905258,0.00001509879,0.001994635,0.004979537],"study_design_scores_gemma":[0.001700251,0.001287552,0.0003493249,0.00002125915,0.00003797887,0.00002694436,0.0002038484,0.0002948304,0.8778204,0.0001891946,0.1177251,0.0003433411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949087,0.0009751685,0.0005929328,0.001487699,0.0004768598,0.001139504,0.00006344384,0.00007352162,0.0002821542],"genre_scores_gemma":[0.9964701,0.0001177578,0.0003139828,0.001644123,0.0005648211,0.0004397357,0.0003336852,0.00008609213,0.00002972898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1157304,"threshold_uncertainty_score":0.9998832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306089607052532,"score_gpt":0.2491607958643796,"score_spread":0.2360998997938543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}