{"id":"W2322061949","doi":"10.1093/neuonc/nou242.8","title":"CS-08 * SONIC HEDGEHOG SIGNALING PROTECTS ATOH1 FROM DEGRADATION MEDIATED BY THE HECT DOMAIN E3 UBIQUITIN LIGASE HUWE1 IN CEREBELLAR GRANULE NEURON PROGENITORS","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Ubiquitin ligase; Sonic hedgehog; Transcription factor; Cell biology; Biology; GLI2; Cerebellum; Ubiquitin; Molecular biology; Genetics; Signal transduction; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008490661,0.0001987497,0.0001772323,0.0001209413,0.0001359576,0.00028498,0.0002706381,0.0002005533,0.001596384],"category_scores_gemma":[0.00008953732,0.0001187373,0.0002064337,0.0001350116,0.0002089877,0.0001624956,0.0001630132,0.0005020791,0.0005752931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733819,"about_ca_system_score_gemma":0.0002559078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008866907,"about_ca_topic_score_gemma":0.001150541,"domain_scores_codex":[0.9998955,0.00001224703,0.0000126917,0.00002464732,0.00002516933,0.00002986097],"domain_scores_gemma":[0.9999112,0.00001206601,0.00002425542,0.00001384403,0.000008784732,0.00002986827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002269386,0.00003864929,0.0002227522,0.00003134058,0.000007100214,0.00004140185,0.000008930966,0.00005267128,0.998068,0.000164443,0.00007442518,0.00106335],"study_design_scores_gemma":[0.00001844495,0.0001430458,0.006664065,0.000004551113,0.00001142906,0.0001545809,0.00002592603,0.001095991,0.9891538,0.00006460684,0.002659307,0.00000417893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960576,0.0008361416,0.001217623,0.0001228759,0.00002174311,0.0000106106,0.0005865127,0.00005526991,0.001091664],"genre_scores_gemma":[0.9935161,0.000340159,0.0009451948,0.00006412603,0.000005406576,0.00001975474,0.001470851,0.00002106299,0.003617253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596384,"threshold_uncertainty_score":0.005340457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306089607052532,"score_gpt":0.2491607958643796,"score_spread":0.2360998997938543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}