{"id":"W2322095595","doi":"10.1089/hum.2016.016","title":"Lentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I","year":2016,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Instituto de Salud Carlos III; Comunidad de Madrid; Wellcome Trust","keywords":"CD18; Leukocyte adhesion deficiency; Haematopoiesis; Biology; Viral vector; CD34; Genetic enhancement; Extravasation; Myeloid; Immunology; Leukocyte extravasation; Molecular biology; Severe combined immunodeficiency; Inflammation; In vivo; Stem cell; Cell biology; Recombinant DNA; Gene; Flow cytometry; Integrin alpha M","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184333,0.000151467,0.0002646165,0.0001275626,0.0001327336,0.000002596197,0.0002224143,0.0001520899,0.0002897081],"category_scores_gemma":[0.00002416636,0.0001068266,0.0001108723,0.0001397997,0.0002740758,0.00008355924,0.00003103548,0.00009177651,0.0000932089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002495139,"about_ca_system_score_gemma":0.00006861761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007545965,"about_ca_topic_score_gemma":0.000002620791,"domain_scores_codex":[0.9990368,0.000107732,0.0003556798,0.0002047683,0.00005108981,0.0002439631],"domain_scores_gemma":[0.9992969,0.00004876479,0.0002256732,0.0003091496,0.0001153435,0.00000417516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004306708,0.0002813568,0.0001849257,0.000006052811,0.00004030169,1.22008e-7,0.0006107292,0.0000794124,0.988455,0.0002419344,0.00008520401,0.00958431],"study_design_scores_gemma":[0.001929413,0.0006168821,0.001663743,0.000027301,0.000010292,0.000001823177,0.00008763799,0.00006037964,0.9949282,0.0001264038,0.0004062828,0.0001416706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885389,0.00980623,0.0003550122,0.00001288175,0.0004727605,0.0001535149,0.00001619285,0.00005134213,0.0005932203],"genre_scores_gemma":[0.9939378,0.0009511387,0.000008775825,0.00002201975,0.000002340167,0.000006590447,0.00004204818,0.00001837021,0.005010844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00944264,"threshold_uncertainty_score":0.4356263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700470627799814,"score_gpt":0.2453774136854376,"score_spread":0.2183727074074394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}