{"id":"W2322095595","doi":"10.1089/hum.2016.016","title":"Lentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I","year":2016,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Instituto de Salud Carlos III; Comunidad de Madrid; Wellcome Trust","keywords":"CD18; Leukocyte adhesion deficiency; Haematopoiesis; Biology; Viral vector; CD34; Genetic enhancement; Extravasation; Myeloid; Immunology; Leukocyte extravasation; Molecular biology; Severe combined immunodeficiency; Inflammation; In vivo; Stem cell; Cell biology; Recombinant DNA; Gene; Flow cytometry; Integrin alpha M","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003997312,0.0008106333,0.000581152,0.001042907,0.0003587841,0.0007047944,0.0007822292,0.001205951,0.003366531],"category_scores_gemma":[0.000233352,0.0003459354,0.0005030531,0.0004988801,0.0005637833,0.0003647048,0.0003218969,0.002362217,0.001044873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005923996,"about_ca_system_score_gemma":0.000518577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008349367,"about_ca_topic_score_gemma":0.0006664984,"domain_scores_codex":[0.9994336,0.00007139891,0.00007335926,0.0001465599,0.0001575756,0.0001174133],"domain_scores_gemma":[0.9996743,0.00004447163,0.00009783213,0.00005127242,0.00003264327,0.00009946842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003166102,0.000323557,0.0002024169,0.00007948183,0.00002149864,0.0002568155,0.00006089802,0.0001741224,0.9940748,0.001162507,0.0003484293,0.002978923],"study_design_scores_gemma":[0.0002861501,0.002126951,0.00253755,0.00005702686,0.00008823005,0.001674413,0.00007628272,0.003235962,0.9648341,0.000314818,0.02474175,0.00002685138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9471416,0.003211071,0.03125815,0.0007471952,0.0007020427,0.0008276014,0.007186894,0.001670306,0.007255022],"genre_scores_gemma":[0.9352957,0.003235984,0.02537913,0.0003866697,0.0001355148,0.001553421,0.007011052,0.0003255034,0.02667707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003366531,"threshold_uncertainty_score":0.01126218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700470627799814,"score_gpt":0.2453774136854376,"score_spread":0.2183727074074394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}