{"id":"W2322105514","doi":"10.1038/mp.2016.37","title":"Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease","year":2016,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Standardized uptake value; Neurodegeneration; Posterior cingulate; Positron emission tomography; Amyloid (mycology); Alzheimer's disease; Biomarker; Pittsburgh compound B; Tau protein; Oncology; Internal medicine; Cognitive decline; Neuroscience; Psychology; Alzheimer's Disease Neuroimaging Initiative; Medicine; Disease; Dementia; Pathology; Chemistry; Cortex (anatomy); Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718084,0.0002928958,0.0004456103,0.000187009,0.00006231398,0.00002363982,0.000136323,0.0001081036,0.0001801514],"category_scores_gemma":[0.0001516711,0.0001959708,0.0002030245,0.0002769524,0.0002200972,0.00009842025,0.000137986,0.0001943758,0.0001222269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002369439,"about_ca_system_score_gemma":0.0004842064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007312799,"about_ca_topic_score_gemma":0.00003875233,"domain_scores_codex":[0.9978253,0.0001502855,0.0004125261,0.0006385321,0.0004418801,0.0005314784],"domain_scores_gemma":[0.9981569,0.00007462316,0.00007254414,0.0005855695,0.00006962239,0.00104074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002559196,0.002405333,0.9565452,0.00004793308,0.006139902,0.001443151,0.00002395783,0.000002312104,0.001482666,0.00297703,0.0008402512,0.02553304],"study_design_scores_gemma":[0.009792889,0.0004068066,0.9782957,0.0003390946,0.001846892,0.00005159658,0.00002545086,0.00007330195,0.00201156,0.004408744,0.002354574,0.0003933386],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8430657,0.1450991,0.00009547473,0.01057432,0.0001804302,0.000546992,0.00004584293,0.00007750783,0.0003146462],"genre_scores_gemma":[0.9949997,0.002251786,0.001091284,0.001309901,0.00009577077,0.0000940314,0.00004607546,0.00005772425,0.00005369195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.151934,"threshold_uncertainty_score":0.7991456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071252897076461,"score_gpt":0.3254988111496838,"score_spread":0.3047862821789192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}