{"id":"W2322121101","doi":"10.1093/infdis/jiw125","title":"Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women","year":2016,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Centers for Disease Control and Prevention; National Institutes of Health; University of Washington; Bill and Melinda Gates Foundation","keywords":"Emtricitabine; Tubulopathy; Medicine; Pre-exposure prophylaxis; Placebo; Glycosuria; Internal medicine; Odds ratio; Renal function; Urology; Gastroenterology; Endocrinology; Kidney disease; Human immunodeficiency virus (HIV); Pathology; Virology; Men who have sex with men; Viral load; Antiretroviral therapy; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005129444,0.0001759761,0.0004110787,0.0002198617,0.00007498344,0.00001161352,0.00005914262,0.00005328267,0.00004101906],"category_scores_gemma":[0.000390491,0.00007539254,0.0000641222,0.0003102751,0.0001236948,0.0001790278,0.00002610343,0.0001468654,0.000002545448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003546008,"about_ca_system_score_gemma":0.0002730892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001437895,"about_ca_topic_score_gemma":0.00001800535,"domain_scores_codex":[0.9986687,0.0002209225,0.0004094978,0.0001153247,0.0003637514,0.0002218442],"domain_scores_gemma":[0.9987259,0.0002138959,0.000519781,0.0001398705,0.0002556874,0.0001448489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002407616,0.001106519,0.9849507,0.00007011515,0.0008117571,0.00005936115,0.00147007,0.00001770297,0.001730163,0.000002934589,0.0001047873,0.007268275],"study_design_scores_gemma":[0.01094646,0.008007099,0.9758987,0.0006876452,0.0007018955,0.0001275549,0.0004412188,0.00002287514,0.002588563,0.0004156865,0.00001728386,0.0001449634],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985476,0.0004713956,0.00007039479,0.0001821586,0.00003284916,0.0004795435,0.00002106469,0.00001882893,0.0001761868],"genre_scores_gemma":[0.9985864,0.0004006068,0.0000123833,0.00001114581,0.00004855427,0.00002600473,0.000002543375,0.00001909448,0.000893227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00905195,"threshold_uncertainty_score":0.3074419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003002469797475019,"score_gpt":0.1887776744625792,"score_spread":0.1857752046651042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}