{"id":"W2322121101","doi":"10.1093/infdis/jiw125","title":"Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women","year":2016,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Mental Health; Centers for Disease Control and Prevention; National Institutes of Health; University of Washington; Bill and Melinda Gates Foundation","keywords":"Emtricitabine; Tubulopathy; Medicine; Pre-exposure prophylaxis; Placebo; Glycosuria; Internal medicine; Odds ratio; Renal function; Urology; Gastroenterology; Endocrinology; Kidney disease; Human immunodeficiency virus (HIV); Pathology; Virology; Men who have sex with men; Viral load; Antiretroviral therapy; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001669657,0.0004130237,0.001014047,0.0005148116,0.0004322341,0.0006440805,0.0003487864,0.0006482942,0.002372309],"category_scores_gemma":[0.00443031,0.0002914692,0.001573332,0.0006398265,0.0003128955,0.0003378692,0.0003522203,0.0004812982,0.0001238573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838655,"about_ca_system_score_gemma":0.0003135414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001841764,"about_ca_topic_score_gemma":0.002173981,"domain_scores_codex":[0.9987615,0.0004736223,0.0001090911,0.0003086049,0.0001938069,0.0001533108],"domain_scores_gemma":[0.9984444,0.0004075305,0.0007608113,0.0001369371,0.00007207823,0.0001782124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00772543,0.000100631,0.9784603,0.0001783784,0.002043931,0.0003696341,0.0001222294,0.00008956285,0.0007120699,0.00008302784,0.0002176032,0.009897229],"study_design_scores_gemma":[0.0004593935,0.00177856,0.9923625,0.00008998936,0.002318432,0.001186,0.0001813217,0.0004642383,0.0002826214,0.0001702889,0.0006951011,0.00001149975],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917817,0.006658789,0.0001507288,0.0001477926,0.00002763117,0.00003474256,0.0002458703,0.00000806293,0.0009447693],"genre_scores_gemma":[0.9993743,0.0003408022,0.00004177796,0.0000421686,0.00002950354,0.000007270958,0.00006206095,0.000001240125,0.0001008172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372309,"threshold_uncertainty_score":0.00883013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003002469797475019,"score_gpt":0.1887776744625792,"score_spread":0.1857752046651042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}