{"id":"W2322121630","doi":"10.1056/nejm200103083441001","title":"Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis","year":2001,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":6149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Royal University Hospital","funders":"","keywords":"Drotrecogin alfa; Medicine; Placebo; Sepsis; Internal medicine; Clinical endpoint; Adverse effect; Randomized controlled trial; Surgery; Septic shock; Severe sepsis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00160032,0.0003864591,0.0009997607,0.0001771301,0.0001544159,0.0003982577,0.0002762761,0.0006303498,0.00132291],"category_scores_gemma":[0.002278231,0.0001419524,0.0007699853,0.0001488002,0.0004524319,0.0002898476,0.000185148,0.00104305,0.0001900977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002682644,"about_ca_system_score_gemma":0.0004578649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001394333,"about_ca_topic_score_gemma":0.0001182303,"domain_scores_codex":[0.9992512,0.0004689162,0.00007314937,0.00006438888,0.00009691207,0.00004532346],"domain_scores_gemma":[0.9989834,0.0003344268,0.0003765122,0.00005743203,0.00006055136,0.0001875968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6496097,0.008145187,0.007266494,0.001905439,0.00142629,0.0001813055,0.0000889339,0.001852714,0.03190497,0.0003795582,0.001344549,0.2958949],"study_design_scores_gemma":[0.4316013,0.5128537,0.03856182,0.0003703681,0.001058109,0.0008944325,0.0000465894,0.001997702,0.008269727,0.0004656027,0.003841656,0.00003900334],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801451,0.0171723,0.0006034117,0.0004600425,0.0001553096,0.0003927988,0.0001614738,0.00002982146,0.000879794],"genre_scores_gemma":[0.9963722,0.002215392,0.0005077581,0.0002547526,0.0001559737,0.0002024532,0.0001536307,0.000002818657,0.0001350964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160032,"threshold_uncertainty_score":0.008463442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06766904450525144,"score_gpt":0.3484623043665551,"score_spread":0.2807932598613037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}