{"id":"W2322128527","doi":"10.1016/j.clpt.2005.12.074","title":"PI-53Effects of propafenone on the pharmacokinetics of caffeine","year":2006,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Propafenone; Caffeine; Pharmacokinetics; Pharmacology; CYP1A2; CYP2D6; Medicine; Drug; Drug interaction; Internal medicine; Metabolism; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001749866,0.0003594206,0.0004367368,0.00009499086,0.00014631,0.0002102129,0.00009942227,0.0002354914,0.003000683],"category_scores_gemma":[0.0007757842,0.0001761138,0.000335613,0.00008764036,0.0001869814,0.0001842135,0.0001308839,0.0004335123,0.0004031736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001548202,"about_ca_system_score_gemma":0.0001510228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003354777,"about_ca_topic_score_gemma":0.0003714635,"domain_scores_codex":[0.9998177,0.00006655243,0.00001033163,0.00002806448,0.00004810302,0.00002926036],"domain_scores_gemma":[0.9997082,0.0001184247,0.00007196686,0.00003021295,0.00002120371,0.00004995297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0895196,0.002211101,0.02298611,0.0004734239,0.0003328248,0.001476548,0.0002350517,0.001384934,0.7518009,0.0001447363,0.0008188064,0.128616],"study_design_scores_gemma":[0.005814628,0.2486116,0.3891979,0.0000537239,0.00101954,0.004708769,0.0002031575,0.01043371,0.3267778,0.0003949991,0.01272578,0.00005834733],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969745,0.001297605,0.0006246059,0.00007219485,0.00002667206,0.00005373576,0.0001097339,0.00002595386,0.0008150873],"genre_scores_gemma":[0.9982944,0.0003209061,0.0003598563,0.00004705343,0.00002612739,0.0000247159,0.0001234602,0.000007290437,0.0007961069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003000683,"threshold_uncertainty_score":0.01003826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09898817495081592,"score_gpt":0.4184030477813123,"score_spread":0.3194148728304964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}