{"id":"W2322260047","doi":"10.1021/ml500077j","title":"Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents","year":2014,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Hepatitis C virus research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Guanosine; Nucleoside; Hepatitis C virus; NS5B; Nucleotide; Sofosbuvir; Chemistry; Glycosidic bond; Uridine; Stereochemistry; Adenosine; Purine; Pharmacology; Biochemistry; Virology; Virus; Hepacivirus; Biology; Ribavirin; Enzyme; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002224706,0.0003311741,0.0002847994,0.0003847629,0.0002159523,0.0003341827,0.0003625192,0.0004572876,0.002532007],"category_scores_gemma":[0.0001771403,0.0001956408,0.0002283769,0.0002777708,0.0001591339,0.0003148897,0.0002813565,0.0004650408,0.0009765523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885822,"about_ca_system_score_gemma":0.0004097217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004899879,"about_ca_topic_score_gemma":0.001455432,"domain_scores_codex":[0.9998977,0.00002370448,0.00001113958,0.00001598133,0.00002878225,0.00002281593],"domain_scores_gemma":[0.9999355,0.000008099526,0.0000104314,0.000007516011,0.00001682264,0.00002161093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003535609,0.0003121724,0.0002994715,0.001319548,0.0000373658,0.001142018,0.0002006302,0.003889313,0.8721297,0.0134755,0.001605412,0.1052354],"study_design_scores_gemma":[0.0002904067,0.003938158,0.001759096,0.0002691337,0.00007822869,0.001130411,0.00006614219,0.004163984,0.8256674,0.002473841,0.1600852,0.00007785953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.746748,0.101382,0.05216392,0.00138082,0.000952793,0.001661769,0.003088843,0.0004458938,0.09217594],"genre_scores_gemma":[0.865029,0.05790902,0.06289075,0.0005995338,0.0001818364,0.0005110935,0.00109952,0.00004972078,0.0117296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002532007,"threshold_uncertainty_score":0.008470416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273452711424175,"score_gpt":0.2757924244150484,"score_spread":0.2630578973008067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}