{"id":"W2322285810","doi":"10.1016/j.neures.2010.07.368","title":"Understanding the mechanistic basis of TDP-43-induced neurotoxicity in amyotrophic lateral sclerosis’","year":2010,"lang":"en","type":"article","venue":"Neuroscience Research","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Amyotrophic lateral sclerosis; Neurotoxicity; Neuroscience; Basis (linear algebra); Medicine; Biology; Pathology; Toxicity; Internal medicine; Disease; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003958318,0.0002045219,0.0003643643,0.0007224345,0.0005309297,0.0001565705,0.001035093,0.0001509417,0.0001714789],"category_scores_gemma":[0.003022568,0.0001366827,0.000114214,0.003206377,0.001398122,0.0002452657,0.0005695063,0.002882441,0.00003489763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252482,"about_ca_system_score_gemma":0.0004984622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004311082,"about_ca_topic_score_gemma":0.0001569097,"domain_scores_codex":[0.9939727,0.0006541894,0.0004740914,0.0007717647,0.002822225,0.001305058],"domain_scores_gemma":[0.997612,0.0006331025,0.00008224793,0.000984169,0.000302021,0.0003864756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001488745,0.0001878953,0.01082855,0.00003912316,0.00000216951,0.00006984467,0.000133971,0.00001240521,0.9850223,0.002976128,0.0001031402,0.0004755833],"study_design_scores_gemma":[0.001419761,0.001369097,0.866093,0.0001983821,0.000008590397,0.0000816883,0.0001273159,0.01930825,0.1077215,0.003311326,0.0001442432,0.0002168645],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885598,0.000006947484,0.0001514661,0.009001466,0.0003304766,0.001183705,0.000005897658,0.0000378856,0.0007223131],"genre_scores_gemma":[0.9988448,0.00008515549,0.00006945198,0.0006082418,0.00008270134,0.00008545269,9.238536e-7,0.00003695915,0.00018633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8773008,"threshold_uncertainty_score":0.999418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4579739826349952,"score_gpt":0.4168267036187115,"score_spread":0.04114727901628373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}