{"id":"W2322459517","doi":"10.1155/2004/571283","title":"Think Stop before Going 'Off-Label'","year":2004,"lang":"en","type":"letter","venue":"Canadian Journal of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Thalidomide; Troglitazone; Drug; Medicine; Off-label use; Clinical trial; Drug approval; Intensive care medicine; Pharmacology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003494805,0.0003130512,0.000921294,0.0004043545,0.0001526687,0.00004006797,0.0003226268,0.0004943812,0.0008603784],"category_scores_gemma":[0.0002391737,0.0002546116,0.0002700547,0.0000843512,0.0002837203,0.0001161536,0.00003117744,0.004307149,0.00006259155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006273006,"about_ca_system_score_gemma":0.001361185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078934,"about_ca_topic_score_gemma":0.0118411,"domain_scores_codex":[0.9977593,0.0001528687,0.0006301921,0.0002243327,0.0002765441,0.0009567161],"domain_scores_gemma":[0.9979705,0.00008256584,0.0005987053,0.0002210353,0.0002713791,0.0008558405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004018711,0.00002213959,0.01445305,0.0001557105,0.0008733413,0.02744623,0.000343673,0.000002828609,0.000004725287,0.00001452895,0.9518256,0.004456281],"study_design_scores_gemma":[0.002292849,0.003689471,0.002151625,0.0003399445,0.0007015407,0.01232065,0.00004169224,0.000007801924,0.000001604685,0.0002429426,0.9781138,0.00009611718],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02400899,0.002795351,0.00004880798,0.9689199,0.002009123,0.000169666,0.00005246101,0.000008082743,0.001987642],"genre_scores_gemma":[0.04401111,0.0003368783,0.0005352562,0.9473888,0.006629684,0.000001673488,0.0000330783,0.00005650954,0.001007061],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02628813,"threshold_uncertainty_score":0.9999906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0383769546439462,"score_gpt":0.3071156650914397,"score_spread":0.2687387104474935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}