{"id":"W2322459517","doi":"10.1155/2004/571283","title":"Think Stop before Going 'Off-Label'","year":2004,"lang":"en","type":"letter","venue":"Canadian Journal of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Thalidomide; Troglitazone; Drug; Medicine; Off-label use; Clinical trial; Drug approval; Intensive care medicine; Pharmacology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005293334,0.0007957534,0.001075256,0.0009723211,0.004321494,0.003870647,0.001904676,0.06541381,0.01210599],"category_scores_gemma":[0.03296216,0.000626567,0.001537952,0.0008594372,0.005694022,0.007465242,0.001607602,0.04892415,0.009044868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006598168,"about_ca_system_score_gemma":0.005683842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01451027,"about_ca_topic_score_gemma":0.02597526,"domain_scores_codex":[0.9947,0.001527017,0.0006861013,0.0005942108,0.001990256,0.0005025511],"domain_scores_gemma":[0.9871996,0.006231149,0.0009195412,0.0004456328,0.002736597,0.002467395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004971639,0.00005969439,0.0009168157,0.00006988272,0.00001543957,0.002008074,0.0002333023,0.000034596,0.0002217954,0.002227766,0.9813731,0.01278968],"study_design_scores_gemma":[0.0001589123,0.0001379363,0.002005007,0.0004724957,0.00003113352,0.006196323,0.001262399,0.0002348559,0.0002357764,0.01170295,0.9774764,0.00008580284],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000176376,0.0007426523,0.00005029762,0.9945586,0.003136233,0.000006876544,0.0000130574,0.00001388111,0.001301949],"genre_scores_gemma":[0.001455636,0.0005709224,0.0002239938,0.988912,0.005736013,0.00001497945,0.00000882224,0.000008841325,0.003068761],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06541381,"threshold_uncertainty_score":0.04787332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0383769546439462,"score_gpt":0.3071156650914397,"score_spread":0.2687387104474935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}