{"id":"W2322471444","doi":"10.1056/nejmoa1507574","title":"Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1032,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Fundación Bunge y Born; Boston Scientific Corporation; World Health Organization; Hamilton Health Sciences; Canadian Institutes of Health Research; Universidade de São Paulo; McMaster University","keywords":"Benznidazole; Medicine; Internal medicine; Placebo; Hazard ratio; Odds ratio; Chagas disease; Cardiomyopathy; Heart transplantation; Heart failure; Confidence interval; Cardiology; Trypanosoma cruzi; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057347,0.0001182344,0.001161651,0.0002741764,0.00002735248,0.000005146734,0.0001456275,0.00006060418,0.0001000728],"category_scores_gemma":[0.004596101,0.00006924047,0.0002738284,0.0001924073,0.000222962,0.00007103267,0.00001831542,0.000239602,0.00000284878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048809,"about_ca_system_score_gemma":0.001144771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000046783,"about_ca_topic_score_gemma":0.000008853569,"domain_scores_codex":[0.9980259,0.0001283101,0.0008150207,0.00009957616,0.0007091098,0.000222116],"domain_scores_gemma":[0.9973251,0.0005798147,0.0004157144,0.0002336173,0.0008047268,0.0006410819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8972463,0.0001149769,0.00004415185,0.00006865295,0.0002992611,0.00002257739,0.0005528028,0.000009676781,0.007348869,0.0008152339,0.0411987,0.05227881],"study_design_scores_gemma":[0.8776575,0.009085828,0.0002371699,0.0001873319,0.0003403746,0.0004668577,0.0001271216,0.00007386215,0.0008783181,0.00117148,0.1097254,0.00004878428],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8768048,0.01487868,0.02274971,0.06398284,0.003016059,0.004337608,0.0000289004,0.00003246967,0.0141689],"genre_scores_gemma":[0.9824963,0.0008549496,0.00099563,0.0001378935,0.01441005,0.0000192553,0.0000154729,0.00001820365,0.001052296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1056914,"threshold_uncertainty_score":0.5502294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06560661444340257,"score_gpt":0.3610738177184126,"score_spread":0.2954672032750101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}