{"id":"W2322522340","doi":"10.1371/journal.ppat.1005546","title":"cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz-Alberta Initiative; Deutsche Forschungsgemeinschaft","keywords":"Human cytomegalovirus; Interferon; Monocyte; Biology; Interferon type I; Sting; SAMHD1; Immune system; Stimulator of interferon genes; Virology; Innate immune system; TLR9; Virus; Immunology; Cell biology; Gene; RNA; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522962,0.0003071,0.0002464052,0.0001645654,0.0001265738,0.0002482164,0.00009212004,0.00022926,0.0007104236],"category_scores_gemma":[0.00008594441,0.000126592,0.0002299167,0.0001661153,0.0001435294,0.00008417293,0.000166472,0.0005070193,0.0003726022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002833029,"about_ca_system_score_gemma":0.0002051956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005778067,"about_ca_topic_score_gemma":0.001024171,"domain_scores_codex":[0.9998185,0.00002562247,0.0000171741,0.00003939987,0.00005266793,0.00004661246],"domain_scores_gemma":[0.9999391,0.000008982463,0.00001417439,0.00001086363,0.000009408398,0.00001751288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005211673,0.000007806925,0.00008683309,0.00002086416,0.000001450471,0.00001874846,0.00000920911,0.00001887364,0.9993258,0.0000285244,0.00003242887,0.0003975704],"study_design_scores_gemma":[0.00001865785,0.0002153819,0.003475007,0.000006204202,0.000009097773,0.0001520322,0.00002507641,0.0005709635,0.9922069,0.00003513793,0.003279992,0.000005578695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867811,0.002476641,0.006144971,0.0001795615,0.00009775771,0.00007984186,0.001615973,0.0002157211,0.002408416],"genre_scores_gemma":[0.9901977,0.0008984393,0.004491404,0.0001496682,0.00001696112,0.00007611732,0.001390226,0.00001967567,0.00275979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007104236,"threshold_uncertainty_score":0.002376616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03647394190849648,"score_gpt":0.2738744687843276,"score_spread":0.2374005268758311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}