{"id":"W2322522340","doi":"10.1371/journal.ppat.1005546","title":"cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz-Alberta Initiative; Deutsche Forschungsgemeinschaft","keywords":"Human cytomegalovirus; Interferon; Monocyte; Biology; Interferon type I; Sting; SAMHD1; Immune system; Stimulator of interferon genes; Virology; Innate immune system; TLR9; Virus; Immunology; Cell biology; Gene; RNA; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002571953,0.0003120089,0.0004426015,0.0003913713,0.0002270781,0.0000321885,0.0002414572,0.0003149713,0.0006200278],"category_scores_gemma":[0.0001786175,0.0002288495,0.00007637807,0.0001342648,0.0003943206,0.000138505,0.0002107346,0.0002739813,0.0006010875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009225957,"about_ca_system_score_gemma":0.0000499679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007436518,"about_ca_topic_score_gemma":0.00007981906,"domain_scores_codex":[0.9978547,0.0006563718,0.0004442669,0.0004773051,0.00004710752,0.0005202755],"domain_scores_gemma":[0.9990031,0.0003412801,0.000128696,0.000405434,0.00008034867,0.00004109978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001476986,0.0001796086,0.002248123,0.00001564614,0.0000968158,0.00005139666,0.0009395385,6.032531e-8,0.9933523,0.0001585815,0.0002359261,0.001245006],"study_design_scores_gemma":[0.001482603,0.001147317,0.01805784,0.0002011621,0.00003485996,0.00004097439,0.0004133799,2.509261e-7,0.9761946,0.00007401774,0.002030258,0.0003227933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972575,0.001281082,0.000007897576,0.0001502538,0.0003056898,0.0002548839,0.00007236086,0.0001118294,0.000558488],"genre_scores_gemma":[0.9929873,0.0002419207,0.0000250024,0.0001182446,0.00003371673,0.00002203936,0.00001702609,0.00004303628,0.006511658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01715777,"threshold_uncertainty_score":0.9332212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03647394190849648,"score_gpt":0.2738744687843276,"score_spread":0.2374005268758311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}