{"id":"W2322543929","doi":"10.1021/jm301661h","title":"Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Stearoyl-CoA Desaturase; Tolerability; Metabolic syndrome; IC50; In vivo; Bioavailability; Pharmacology; Biochemistry; In vitro; Internal medicine; Obesity; Gene; Adverse effect; Biology; Medicine; Gene expression; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329969,0.0004053065,0.0003691537,0.0002474241,0.00009642341,0.0001876406,0.0002417057,0.0001886062,0.0009212848],"category_scores_gemma":[0.0001019239,0.0001505955,0.000153769,0.0001610383,0.000163828,0.0001957913,0.0002206644,0.0005203012,0.0003134365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011173,"about_ca_system_score_gemma":0.0001864048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002965975,"about_ca_topic_score_gemma":0.001341975,"domain_scores_codex":[0.9999564,0.000009160459,0.000002911958,0.000008087068,0.00001055962,0.00001293502],"domain_scores_gemma":[0.9999635,0.00000534131,0.00001228234,0.000002317385,0.000005822216,0.00001073442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007399041,0.0003602325,0.0006072527,0.0003053813,0.00004449296,0.0005060961,0.00006522719,0.00170672,0.9299833,0.001116887,0.0009572514,0.0636074],"study_design_scores_gemma":[0.002438833,0.01317524,0.01116335,0.00009090055,0.0002458392,0.003487552,0.00007496304,0.00787595,0.9167374,0.0006568395,0.04398429,0.00006869536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581496,0.02084086,0.01221444,0.0006614718,0.0001166421,0.0004003672,0.0008043968,0.0003215495,0.006490683],"genre_scores_gemma":[0.9750828,0.0136083,0.007250976,0.0002204919,0.00003654921,0.0000943403,0.0008359498,0.00001758443,0.002853022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009212848,"threshold_uncertainty_score":0.003081977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008424923730242131,"score_gpt":0.2419896974520986,"score_spread":0.2335647737218564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}