{"id":"W2322545202","doi":"10.1021/cb4006722","title":"Discovery of Light-Responsive Ligands through Screening of a Light-Responsive Genetically Encoded Library","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Streptavidin; Azobenzene; Peptide library; Chemistry; Linker; Ligand (biochemistry); Combinatorial chemistry; Phage display; Electrospray ionization; Stereochemistry; Biophysics; Peptide; Receptor; Biochemistry; Mass spectrometry; Biology; Peptide sequence; Biotin; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003362156,0.0005649958,0.000556608,0.0004935711,0.0001653061,0.0004547852,0.0004310322,0.0003728374,0.0008054966],"category_scores_gemma":[0.0004165138,0.0002190152,0.0002867562,0.0003728045,0.0002046007,0.0002424084,0.0004144145,0.0005945633,0.0005248857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003956642,"about_ca_system_score_gemma":0.000327081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003164384,"about_ca_topic_score_gemma":0.0008189357,"domain_scores_codex":[0.9996701,0.00005396622,0.00002358527,0.00006744574,0.0001312114,0.0000536713],"domain_scores_gemma":[0.9997342,0.00006860784,0.00005659718,0.00003061082,0.00004970478,0.00006026388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002476787,0.00003570017,0.0001194521,0.00002145049,0.000004551667,0.0000386061,0.000009622344,0.0002265583,0.9972149,0.00006109481,0.00002164439,0.002221788],"study_design_scores_gemma":[0.00001127244,0.0003931814,0.00062413,0.000004549258,0.00001861574,0.0001558203,0.00001952402,0.001335519,0.995683,0.00003120019,0.001716127,0.000007139066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542632,0.001351805,0.03982799,0.0002007892,0.00003727519,0.0004230486,0.0006575645,0.0004802566,0.002758011],"genre_scores_gemma":[0.924432,0.002571747,0.06246802,0.000307835,0.00003149687,0.0004068084,0.002232508,0.0001677511,0.007381756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008054966,"threshold_uncertainty_score":0.002870798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297618318572705,"score_gpt":0.2535113951215693,"score_spread":0.2405352119358422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}