{"id":"W2322578512","doi":"10.1038/ncomms11008","title":"Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error","year":2016,"lang":"en","type":"review","venue":"Nature Communications","topic":"Ophthalmology and Visual Impairment Studies","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute; Johns Hopkins Bloomberg School of Public Health; School of Medicine and Public Health, University of Wisconsin-Madison; Max Planck Instituut voor Psycholinguïstiek; National Institutes of Health; State Key Laboratory of Ophthalmology; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Moorfields Eye Hospital NHS Foundation Trust; National Healthcare Group; Tays; Institute of Genetics; Tartu Ülikool; Hospital for Sick Children; QIMR Berghofer Medical Research Institute; Turun Yliopisto; Capital Medical University; Institut National de la Santé et de la Recherche Médicale; Menzies Research Institute Tasmania; King's College London; Health Science Center, University of Tennessee; National Institute for Health and Care Research; Erasmus Medisch Centrum; Helsingin Yliopisto; Inselspital, Universitätsspital Bern; Menzies Institute for Medical Research; University of Bristol; Turun Yliopistollinen Keskussairaala; Sun Yat-sen University; Cardiff University; University of Toronto; National University of Singapore; Case Western Reserve University; Johns Hopkins University; Tampereen Yliopisto; University of Pennsylvania; Medical Research Council; Genome Institute of Singapore; Wellcome Trust; Diamantina Institute, University of Queensland; University of Tasmania","keywords":"Genome-wide association study; Single-nucleotide polymorphism; SNP; Genetics; Biology; Meta-analysis; Genetic association; Refractive error; Gene; Computational biology; Medicine; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008408929,0.0003232232,0.002382421,0.0005526451,0.0004783235,0.00001787925,0.0005021931,0.0008292554,0.0006011658],"category_scores_gemma":[0.002936447,0.0002404388,0.002748036,0.0004354096,0.0001406544,0.0001637477,0.0001495475,0.0005855562,0.00001830122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005969302,"about_ca_system_score_gemma":0.0004798467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000794359,"about_ca_topic_score_gemma":0.00003103426,"domain_scores_codex":[0.9980243,0.0002529744,0.0008368042,0.0003691146,0.0002929801,0.0002237911],"domain_scores_gemma":[0.9872092,0.008915712,0.00184375,0.001210361,0.0007725417,0.00004842076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007054265,0.002487993,0.0009243381,0.004973674,0.7364343,1.883286e-7,0.0002662502,0.000001838944,0.000006909193,0.001995717,0.220698,0.03214025],"study_design_scores_gemma":[0.0001483214,0.00006464308,0.001891332,0.0003304114,0.3468275,0.000001867315,0.00007364075,0.000005375743,0.000002489405,0.0001627713,0.6503393,0.0001523072],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00000488466,0.9691403,0.0004519969,0.003256411,0.0001466726,0.002242689,0.02441902,0.00002104427,0.0003169726],"genre_scores_gemma":[0.000497972,0.9370721,0.01163552,0.0003807243,0.0001605444,0.005890952,0.03563283,0.00004976696,0.008679596],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4296413,"threshold_uncertainty_score":0.980481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2612799122897091,"score_gpt":0.4831840654532525,"score_spread":0.2219041531635434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}