{"id":"W2322578512","doi":"10.1038/ncomms11008","title":"Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error","year":2016,"lang":"en","type":"review","venue":"Nature Communications","topic":"Ophthalmology and Visual Impairment Studies","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute; Johns Hopkins Bloomberg School of Public Health; School of Medicine and Public Health, University of Wisconsin-Madison; Max Planck Instituut voor Psycholinguïstiek; National Institutes of Health; State Key Laboratory of Ophthalmology; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Moorfields Eye Hospital NHS Foundation Trust; National Healthcare Group; Tays; Institute of Genetics; Tartu Ülikool; Hospital for Sick Children; QIMR Berghofer Medical Research Institute; Turun Yliopisto; Capital Medical University; Institut National de la Santé et de la Recherche Médicale; Menzies Research Institute Tasmania; King's College London; Health Science Center, University of Tennessee; National Institute for Health and Care Research; Erasmus Medisch Centrum; Helsingin Yliopisto; Inselspital, Universitätsspital Bern; Menzies Institute for Medical Research; University of Bristol; Turun Yliopistollinen Keskussairaala; Sun Yat-sen University; Cardiff University; University of Toronto; National University of Singapore; Case Western Reserve University; Johns Hopkins University; Tampereen Yliopisto; University of Pennsylvania; Medical Research Council; Genome Institute of Singapore; Wellcome Trust; Diamantina Institute, University of Queensland; University of Tasmania","keywords":"Genome-wide association study; Single-nucleotide polymorphism; SNP; Genetics; Biology; Meta-analysis; Genetic association; Refractive error; Gene; Computational biology; Medicine; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006849653,0.001794036,0.008126773,0.003773066,0.0003533966,0.001753843,0.00140049,0.0012615,0.002411684],"category_scores_gemma":[0.01302218,0.0006493899,0.01459023,0.005066751,0.0003565136,0.0007767563,0.0009862623,0.001380272,0.0003139072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000799568,"about_ca_system_score_gemma":0.001767371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003345649,"about_ca_topic_score_gemma":0.00930714,"domain_scores_codex":[0.9969251,0.001455753,0.0006336946,0.0005208634,0.0003390703,0.0001256372],"domain_scores_gemma":[0.9913349,0.006970349,0.0007429431,0.000440477,0.0003975687,0.0001138057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002771073,0.00005919621,0.03886054,0.1159039,0.6633261,0.0004801686,0.0001110085,0.001223202,0.001204243,0.0006164283,0.003810037,0.1716341],"study_design_scores_gemma":[0.0004869998,0.0004141344,0.04064146,0.01024698,0.9304532,0.0007887647,0.00008849669,0.0004891371,0.0006778518,0.001512369,0.01415044,0.00005018484],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00343984,0.9950513,0.0006368819,0.0002087857,0.00009346107,0.00002890141,0.0003266028,0.00002183091,0.0001923494],"genre_scores_gemma":[0.115857,0.878266,0.003137552,0.0006854278,0.0002316665,0.0001376573,0.001318807,0.00003964681,0.0003262211],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008126773,"threshold_uncertainty_score":0.03622484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2612799122897091,"score_gpt":0.4831840654532525,"score_spread":0.2219041531635434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}