{"id":"W2322695360","doi":"10.1016/j.ejmech.2016.04.010","title":"Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds","year":2016,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Drugs for Neglected Diseases initiative; School of Medicine, New York University; York University; NorthShore University HealthSystem; Bill and Melinda Gates Foundation","keywords":"Chemistry; Lipophilicity; Trypanosoma brucei; Trypanosoma cruzi; Benznidazole; Leishmania donovani; Trypanosoma brucei rhodesiense; Amastigote; Leishmania; Nitro; Chagas disease; Stereochemistry; Active compound; Antiprotozoal; Biochemistry; In vitro; Organic chemistry; Parasite hosting; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033254,0.0003397581,0.0002309399,0.0002075096,0.0001080812,0.00009915348,0.0002145139,0.0002084442,0.001221486],"category_scores_gemma":[0.0001153627,0.00009266982,0.0001576,0.0001415861,0.0001166007,0.0001158601,0.000108213,0.0002762893,0.0002569751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00012984,"about_ca_system_score_gemma":0.0001526339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004947032,"about_ca_topic_score_gemma":0.001721631,"domain_scores_codex":[0.9999493,0.00001244412,0.000005278543,0.000007109033,0.00001353904,0.00001229104],"domain_scores_gemma":[0.9999393,0.00000991701,0.00001566585,0.000004173937,0.00001514822,0.00001580197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002268513,0.0000762865,0.0002472204,0.0001709596,0.00001072167,0.0001856286,0.00002746542,0.0002716588,0.9930186,0.00007700619,0.00007023814,0.005617297],"study_design_scores_gemma":[0.000221121,0.009938486,0.01115085,0.00005801209,0.0001026413,0.001503825,0.00006688954,0.00113851,0.9670109,0.00006949604,0.008718914,0.00002044874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848987,0.008197053,0.001601646,0.0001028924,0.00003641856,0.00009329493,0.0003204258,0.00005868307,0.004690791],"genre_scores_gemma":[0.9907725,0.004608029,0.002215528,0.00006915881,0.00001941801,0.00004459283,0.0004386217,0.000005779749,0.00182641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221486,"threshold_uncertainty_score":0.004086256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02533260887429616,"score_gpt":0.2810116753257383,"score_spread":0.2556790664514421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}