{"id":"W2322775024","doi":"10.1021/jm400633d","title":"Optimization of Furin Inhibitors To Protect against the Activation of Influenza Hemagglutinin H5 and Shiga Toxin","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Furin; Hemagglutinin (influenza); Toxin; Shiga toxin; Virology; Microbiology; Enzyme; Biochemistry; Virulence; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002144143,0.0004561639,0.00038172,0.0002325314,0.0001617044,0.0003215512,0.0003276358,0.0002487874,0.0007604977],"category_scores_gemma":[0.0001278018,0.0001536658,0.0002087403,0.0001928293,0.000158755,0.0001984981,0.0001178375,0.0005222918,0.0001834558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696094,"about_ca_system_score_gemma":0.0002858047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007043537,"about_ca_topic_score_gemma":0.001704744,"domain_scores_codex":[0.9998477,0.00002283274,0.00001871323,0.00002964051,0.00004515511,0.00003594521],"domain_scores_gemma":[0.9999244,0.0000137679,0.00002594674,0.000005569608,0.00001238404,0.00001790044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002311354,0.0001561828,0.0001000515,0.00004856209,0.00001168572,0.00004185986,0.000009786035,0.0007049165,0.9955557,0.0001099556,0.00007975138,0.002950427],"study_design_scores_gemma":[0.00005444916,0.0008005903,0.0007162442,0.000004967712,0.0000231952,0.00006836624,0.000007686253,0.00136184,0.9942716,0.00002456933,0.002660429,0.000006028608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889717,0.002569317,0.005491696,0.00009969144,0.00003871893,0.0001824466,0.0005939309,0.00008754017,0.001965069],"genre_scores_gemma":[0.9896023,0.001803102,0.006168005,0.00005785122,0.000009150773,0.000107055,0.0005590041,0.00002298936,0.001670602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007604977,"threshold_uncertainty_score":0.002681732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692483343701991,"score_gpt":0.3289687336076326,"score_spread":0.2920439001706127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}