{"id":"W2322831770","doi":"10.1038/sj.leu.2402077","title":"Adenovector engineered interleukin-2 expressing autologous plasma cell vaccination after high-dose chemotherapy for multiple myeloma - a phase 1 study","year":2001,"lang":"en","type":"article","venue":"Leukemia","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Multiple myeloma; Vaccination; Immunology; CD8; Chemotherapy; Plasma cell; Cytotoxic T cell; Internal medicine; Bone marrow; Autologous stem-cell transplantation; Antibody; Cancer research; Oncology; Immune system; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002410853,0.0003881295,0.0004686954,0.000235435,0.0002529889,0.0000446075,0.0003384181,0.0003496791,0.0008322828],"category_scores_gemma":[0.00008769177,0.0003565203,0.0001818415,0.0001852958,0.00005809668,0.0002320686,0.0000518297,0.0003308332,0.0001572707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003937438,"about_ca_system_score_gemma":0.0001492821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001166638,"about_ca_topic_score_gemma":0.00002578373,"domain_scores_codex":[0.9981433,0.0002292933,0.0005074769,0.0004817755,0.00005459641,0.0005835705],"domain_scores_gemma":[0.9987723,0.0004409405,0.0001920237,0.0004903053,0.00007753246,0.00002690119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02038731,0.001290959,0.0008332966,0.00003082363,0.0003192551,0.00003651088,0.004517585,0.00002284377,0.905413,0.000009340862,0.0009377316,0.06620135],"study_design_scores_gemma":[0.057461,0.00305933,0.04452194,0.00006208629,0.000103822,0.0001374588,0.0009636505,0.0005675881,0.8199465,0.00003484908,0.07244281,0.000698945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924889,0.002208547,0.002477807,0.0001056191,0.001007172,0.001358066,0.00004826348,0.0002403698,0.00006531797],"genre_scores_gemma":[0.9924487,0.00006222619,0.0005716312,0.000200807,0.00008783448,0.0005465515,0.0001293103,0.0000790441,0.005873839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08546648,"threshold_uncertainty_score":0.9998887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081485154645055,"score_gpt":0.2544875128482483,"score_spread":0.2436726613017978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}