{"id":"W2322849365","doi":"10.1093/nar/gkw204","title":"Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Replication (statistics); DNA replication; DNA; Adduct; Genetics; Mechanism (biology); Benzo(a)pyrene; DNA polymerase; Molecular biology; Polymerase; Virology; Carcinogen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485213,0.0003223671,0.0002444178,0.0001938145,0.0002828751,0.0005814215,0.0004444549,0.0004900189,0.001224381],"category_scores_gemma":[0.0002901921,0.0003653188,0.0003079291,0.0001246203,0.0003067372,0.0005245288,0.0002330852,0.0003876145,0.0007545333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006960744,"about_ca_system_score_gemma":0.0003134553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002855,"about_ca_topic_score_gemma":0.0004826498,"domain_scores_codex":[0.9998875,0.00001108073,0.000005687368,0.00004602392,0.00003260891,0.00001697753],"domain_scores_gemma":[0.999848,0.00002092515,0.00006224398,0.00002198415,0.00002038407,0.00002646818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004569419,0.0000827885,0.002543995,0.0002336523,0.00004201603,0.000643077,0.0002504046,0.006691684,0.9783958,0.003290283,0.0002671579,0.007102211],"study_design_scores_gemma":[0.0001141534,0.0008022483,0.008135374,0.00005533982,0.00004414836,0.001084545,0.0001597015,0.02091101,0.9563708,0.001685038,0.01056522,0.00007239499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714428,0.008152285,0.01519201,0.0002640141,0.00008101109,0.00006109261,0.0004032903,0.0002803782,0.004122963],"genre_scores_gemma":[0.9931947,0.001627729,0.002585421,0.000037957,0.00001296311,0.00001708926,0.0003593661,0.00001715369,0.002147679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224381,"threshold_uncertainty_score":0.005050421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02445541993861264,"score_gpt":0.3172470339163058,"score_spread":0.2927916139776932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}