{"id":"W2322920786","doi":"10.1021/jo3001657","title":"Formation of Optically Pure Cyclic Amines by Intramolecular Conjugate Displacement","year":2012,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Stereocenter; Intramolecular force; Conjugate; Adduct; Optically active; Stereochemistry; Reduction (mathematics); Medicinal chemistry; Organic chemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003255494,0.0004933898,0.0002178761,0.0002265564,0.0001597181,0.0002688232,0.0003583393,0.0003109687,0.001577497],"category_scores_gemma":[0.0002689281,0.0001975322,0.0002518964,0.0001734803,0.0003054893,0.0002950685,0.0004749896,0.0006869111,0.000500677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002341003,"about_ca_system_score_gemma":0.0002275635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002898802,"about_ca_topic_score_gemma":0.0007054826,"domain_scores_codex":[0.999806,0.000033304,0.00001496084,0.00004382549,0.00004646062,0.00005540526],"domain_scores_gemma":[0.9998373,0.00002486827,0.00004456664,0.00003235228,0.00002832069,0.00003257104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008514582,0.00003789018,0.0001385932,0.00006374179,0.00001130459,0.0000973929,0.0000749051,0.0002104249,0.9918056,0.001027902,0.00008062228,0.006366448],"study_design_scores_gemma":[0.00001421674,0.0002169177,0.0001550568,0.000002057698,0.000006836143,0.00005489689,0.00000633543,0.0001597936,0.9977242,0.00003344374,0.001621538,0.000004674408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632722,0.001065916,0.02234145,0.0001065497,0.00008466428,0.0001581182,0.0002755361,0.0002128401,0.01248266],"genre_scores_gemma":[0.9892538,0.0005501283,0.006565573,0.00003178199,0.00001296179,0.00004436595,0.0001942784,0.00003204437,0.003315106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001577497,"threshold_uncertainty_score":0.005277276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00506079977846303,"score_gpt":0.2041952305077775,"score_spread":0.1991344307293145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}