{"id":"W2322936872","doi":"10.1021/cb400052s","title":"Chaperones Rejuvenate Folding and Activity of 3-β Hydroxysteroid Dehydrogenase 2","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Dehydrogenase; Protein folding; Biology; Folding (DSP implementation); Chaperone (clinical); Hydroxysteroid dehydrogenase; Cell biology; Biochemistry; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005107516,0.00007190715,0.0002326467,0.00003452694,0.00001564811,0.000002106667,0.00002901772,0.0001207247,0.00006142034],"category_scores_gemma":[0.0001036314,0.0000516142,0.00003160195,0.00004678615,0.0001184068,0.00003594524,0.00004728318,0.00007409413,0.00001981497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000115693,"about_ca_system_score_gemma":0.00001071711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003462077,"about_ca_topic_score_gemma":4.533177e-7,"domain_scores_codex":[0.999538,0.00001615746,0.000123843,0.0001496141,0.00004796654,0.0001244114],"domain_scores_gemma":[0.999641,0.000065483,0.00004455521,0.0001076864,0.00005032594,0.00009096578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004567944,0.00003421666,0.002370842,0.00001430696,0.00001728717,0.000002078777,0.00002174006,3.854154e-8,0.9753588,0.0001678766,0.00005657335,0.02191058],"study_design_scores_gemma":[0.0006258295,0.0001150692,0.007083683,0.00001951942,0.00001961762,0.00007960272,0.00000840014,0.0005984224,0.9895473,0.0004606811,0.001382891,0.0000590087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997448,0.000311075,0.00001761367,0.001682616,0.00001865584,0.0001210018,0.000001512069,0.00001835805,0.0003811975],"genre_scores_gemma":[0.9993184,0.00006218572,0.0002021809,0.0003138542,0.0000313844,0.000006932406,0.0000101019,0.000006092579,0.00004885704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02185157,"threshold_uncertainty_score":0.2104766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777926990332523,"score_gpt":0.2596558635713935,"score_spread":0.2418765936680683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}