{"id":"W2323146919","doi":"10.1158/1538-7445.am2013-lb-133","title":"Abstract LB-133: A novel tumor suppressor role for sirt1 inhibiting mitophagy in prostate mouse tissue.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Mitophagy; Sirtuin 1; Carcinogenesis; Prostate cancer; Cancer research; Sirtuin; Autophagy; Biology; Prostate; Cancer; Oncogene; Gene knockdown; Genetically modified mouse; Cell biology; Transgene; NAD+ kinase; Downregulation and upregulation; Cell culture; Apoptosis; Cell cycle; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320165,0.0006417821,0.0003272631,0.0006503264,0.0002707325,0.0002957016,0.0004674809,0.0004307691,0.003063755],"category_scores_gemma":[0.00006986238,0.0002235142,0.0005073949,0.0003543737,0.000460961,0.0002308183,0.0002097093,0.0008264434,0.0008581787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004582778,"about_ca_system_score_gemma":0.0004531304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009582247,"about_ca_topic_score_gemma":0.001456632,"domain_scores_codex":[0.9998491,0.00002316816,0.00001196591,0.00003274515,0.00004209318,0.0000409749],"domain_scores_gemma":[0.9998854,0.00001101415,0.00003953263,0.00001081042,0.000007629113,0.00004549275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002123802,0.00007926831,0.0001038831,0.00008575609,0.00001042535,0.000145758,0.000009179719,0.00007040897,0.9973797,0.0002661647,0.0002367919,0.001400302],"study_design_scores_gemma":[0.0001198834,0.001277189,0.003620782,0.00001940717,0.00006582194,0.001156565,0.00002640006,0.001003061,0.9847733,0.0001139777,0.007812585,0.00001098197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633989,0.008100787,0.01212364,0.001361035,0.00026207,0.0002382039,0.005307027,0.001579542,0.007628812],"genre_scores_gemma":[0.9743824,0.002718145,0.006410337,0.0002600467,0.00003927957,0.0001933803,0.004860537,0.00008802121,0.01104791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003063755,"threshold_uncertainty_score":0.01024932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307775752995527,"score_gpt":0.3538932821527919,"score_spread":0.3208155246228366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}