{"id":"W2323183075","doi":"10.1038/srep23821","title":"CD4+ and CD8+ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Cancer Institute; Universiteit Leiden; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Avidity; T-cell receptor; Cytotoxic T cell; CD8; Biology; Cell biology; Immunology; T cell; Antigen; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001839038,0.0002916341,0.0005268279,0.0003552616,0.000383817,0.0003858971,0.0001673572,0.0001292278,0.002868579],"category_scores_gemma":[0.0002734911,0.0001795732,0.0001576618,0.0004263578,0.0004620514,0.0001705085,0.0002740928,0.0001526489,0.0001017711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001813831,"about_ca_system_score_gemma":0.0002199585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002645289,"about_ca_topic_score_gemma":0.00007611486,"domain_scores_codex":[0.995755,0.0001337347,0.0006948678,0.00147304,0.001225846,0.0007175626],"domain_scores_gemma":[0.9968562,0.00009773615,0.0001999001,0.00172917,0.0004102234,0.0007067535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001276522,0.0001540946,0.005860061,0.00004392473,0.00004897123,0.00176959,0.0001404653,0.000002130733,0.9335738,0.00002440489,0.02566147,0.03259343],"study_design_scores_gemma":[0.0006420552,0.0002375141,0.0197856,0.0001785231,0.00004904434,0.0008221208,0.0000437001,0.00001306979,0.9262129,0.00165358,0.05006227,0.0002996085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877813,0.0002435696,0.000469114,0.002708742,0.007180041,0.0009565944,0.00000920093,0.0001586461,0.0004927523],"genre_scores_gemma":[0.8898848,0.00007115798,0.0003532885,0.0001182618,0.0003360342,0.0000496501,0.00001412929,0.00005554355,0.1091172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1086244,"threshold_uncertainty_score":0.9980429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02877218904447551,"score_gpt":0.2961667845341548,"score_spread":0.2673945954896794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}