{"id":"W2323183075","doi":"10.1038/srep23821","title":"CD4+ and CD8+ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Cancer Institute; Universiteit Leiden; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Avidity; T-cell receptor; Cytotoxic T cell; CD8; Biology; Cell biology; Immunology; T cell; Antigen; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374937,0.0003247562,0.0002404631,0.0002080973,0.000138082,0.0004979538,0.0002108018,0.0003243162,0.001501557],"category_scores_gemma":[0.0002301367,0.0001501115,0.0001949449,0.0001636161,0.0002339627,0.0002931201,0.0004297,0.0006643232,0.000569206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001354059,"about_ca_system_score_gemma":0.00009819795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009870199,"about_ca_topic_score_gemma":0.0001728237,"domain_scores_codex":[0.9997317,0.00003898544,0.00002077582,0.00004727543,0.00005901528,0.0001023182],"domain_scores_gemma":[0.9997979,0.00004605282,0.0000339578,0.0000424324,0.00002036067,0.00005931072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008566838,0.00001774742,0.000932352,0.00001373409,0.000004837244,0.00003209187,0.00002367159,0.0000664777,0.9957574,0.00009586995,0.00001624087,0.002953772],"study_design_scores_gemma":[0.00007831114,0.001402318,0.03253102,0.0000141465,0.00007466439,0.003201133,0.0002320639,0.002922702,0.9541666,0.0007206455,0.004640487,0.00001593891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954665,0.0004050078,0.002713885,0.00002726501,0.000005352424,0.00001052478,0.00003936445,0.00005482136,0.001277345],"genre_scores_gemma":[0.9976382,0.000146431,0.001391071,0.00003714667,0.000007152349,0.00001269799,0.0001229353,0.00001857469,0.0006258275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501557,"threshold_uncertainty_score":0.005023241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02877218904447551,"score_gpt":0.2961667845341548,"score_spread":0.2673945954896794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}