{"id":"W2323192953","doi":"10.1158/1538-7445.am2011-2799","title":"Abstract 2799: Unexpected sustained hypoxic glutamine metabolism and therapeutic opportunities","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Research Council (Canada)","funders":"","keywords":"Glutaminolysis; Glutamine; Glutaminase; Glycolysis; Citric acid cycle; Anabolism; Hypoxia (environmental); Catabolism; Biochemistry; Biology; Metabolism; Glutamine amidotransferase; Glucose transporter; Metabolic pathway; Chemistry; Amino acid; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543156,0.0003418304,0.0002489663,0.0001942813,0.0001112709,0.0004136667,0.0002591259,0.0004129668,0.002462407],"category_scores_gemma":[0.00007422834,0.00008893918,0.0001625939,0.0002111561,0.000212764,0.0002240719,0.0002675234,0.0005945859,0.0007882685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310811,"about_ca_system_score_gemma":0.0002543331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001530291,"about_ca_topic_score_gemma":0.000307604,"domain_scores_codex":[0.9999462,0.000007858474,0.000003537339,0.00001285215,0.00001406134,0.00001540917],"domain_scores_gemma":[0.9999567,0.000003609319,0.00001108754,0.000003863536,0.000008257056,0.000016488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001093554,0.0001935459,0.0006333346,0.0004817812,0.0000328513,0.000696955,0.00001998576,0.0002524719,0.9512152,0.001619151,0.004741325,0.03901984],"study_design_scores_gemma":[0.0006348298,0.004650615,0.01006408,0.000195031,0.0001736656,0.006591061,0.0001232159,0.002604459,0.8365642,0.003215006,0.1351545,0.00002934233],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8320221,0.09219097,0.02662992,0.01065479,0.001853407,0.0004031063,0.004045222,0.001050843,0.03114955],"genre_scores_gemma":[0.9388557,0.03051321,0.007965125,0.001998358,0.0005286271,0.0002029017,0.002838544,0.0001420318,0.0169556],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002462407,"threshold_uncertainty_score":0.0082376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1282179259729351,"score_gpt":0.3560585674883824,"score_spread":0.2278406415154473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}