{"id":"W2323304212","doi":"10.1101/gad.277665.116","title":"PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Alberta Innovates; Alberta Innovates - Health Solutions; National Science Foundation","keywords":"Biology; SUMO protein; Relocation; Ubiquitin ligase; Cell biology; DNA damage; Ubiquitin; DNA; Budding yeast; Nuclear pore; DNA repair; RAD51; DNA ligase; Molecular biology; Genetics; Saccharomyces cerevisiae; Yeast; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009427921,0.0002930368,0.0001484125,0.00009674264,0.00011537,0.0002542444,0.0001783165,0.0001691891,0.001054864],"category_scores_gemma":[0.0000692927,0.0001636931,0.0001955178,0.0001002971,0.0001851138,0.0001810013,0.000327275,0.0003023674,0.0003719511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005105493,"about_ca_system_score_gemma":0.0001490907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007387295,"about_ca_topic_score_gemma":0.001642644,"domain_scores_codex":[0.9999127,0.000011838,0.000009364333,0.00002177603,0.00002050231,0.00002377584],"domain_scores_gemma":[0.9999231,0.000008522809,0.00003024952,0.00001033493,0.000004249905,0.00002347942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306648,0.00001010815,0.0001542628,0.00001714155,0.000003720966,0.00003245557,0.00000987271,0.00005730085,0.9990446,0.00007682991,0.00002054287,0.0004424935],"study_design_scores_gemma":[0.000008215904,0.0000664394,0.002120269,0.000001329176,0.000003550344,0.00006001196,0.00001371744,0.0004271874,0.996445,0.00001904064,0.0008335698,0.000001703292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978611,0.0004264159,0.0008574918,0.00003914288,0.000008151751,0.000007269863,0.0001265929,0.00004426132,0.0006295512],"genre_scores_gemma":[0.9962717,0.0002534573,0.0007228236,0.0000202033,0.000002805193,0.00001072899,0.0003519141,0.0000205708,0.002345737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054864,"threshold_uncertainty_score":0.00370425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006818961769245679,"score_gpt":0.2200088620876287,"score_spread":0.213189900318383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}