{"id":"W2323304212","doi":"10.1101/gad.277665.116","title":"PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL","year":2016,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis Foundation; Alberta Innovates; Alberta Innovates - Health Solutions; National Science Foundation","keywords":"Biology; SUMO protein; Relocation; Ubiquitin ligase; Cell biology; DNA damage; Ubiquitin; DNA; Budding yeast; Nuclear pore; DNA repair; RAD51; DNA ligase; Molecular biology; Genetics; Saccharomyces cerevisiae; Yeast; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816079,0.0001247536,0.0001046536,0.00002315698,0.00008734153,0.00001322135,0.0001446815,0.00008494544,0.00002090933],"category_scores_gemma":[0.00003503422,0.00007992503,0.00002860385,0.00006917259,0.00004372406,0.00000673327,0.0001258229,0.00002019418,0.00001429507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002733891,"about_ca_system_score_gemma":0.00007730143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000207602,"about_ca_topic_score_gemma":0.00001459855,"domain_scores_codex":[0.9991173,0.00004059612,0.0002305849,0.0002801065,0.0001636235,0.000167766],"domain_scores_gemma":[0.9995183,0.00001309041,0.00009076335,0.0002550684,0.0000729192,0.00004984009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004961171,0.00002040269,0.0002363273,0.000007224128,0.00004305557,2.420215e-7,0.0004585768,0.000002496264,0.9128387,0.0001838292,0.003015919,0.08314362],"study_design_scores_gemma":[0.0002585938,0.00008709726,0.003156055,0.00001693159,0.000009375249,0.000004094956,0.000160077,0.000002155208,0.8089378,0.0001072553,0.1871368,0.0001237502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936396,0.000755195,0.003782467,0.001028419,0.0001069599,0.0002782843,0.000009116802,0.00001636872,0.0003835397],"genre_scores_gemma":[0.9925081,0.0004379025,0.005667459,0.0003587573,0.00004356423,0.00002955095,0.00002833644,0.00002231858,0.000904054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1841209,"threshold_uncertainty_score":0.3259248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006818961769245679,"score_gpt":0.2200088620876287,"score_spread":0.213189900318383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}