{"id":"W2323323362","doi":"10.1089/humc.2014.154","title":"Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy","year":2015,"lang":"en","type":"review","venue":"Human Gene Therapy Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis; Genetic enhancement; Disease; Biology; Phenotype; Gene; Animal model; Gene delivery; Viral vector; Bioinformatics; Recombinant DNA; Computational biology; Cancer research; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002606164,0.0007555541,0.002007601,0.0001477591,0.0001925957,0.0000662516,0.0005756857,0.0007306887,0.00001768428],"category_scores_gemma":[0.00006478535,0.0005944872,0.0003897862,0.0001361773,0.0003690271,0.000008335358,0.0002788985,0.0003171195,0.000003785189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006186926,"about_ca_system_score_gemma":0.001560645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002883035,"about_ca_topic_score_gemma":0.00001358316,"domain_scores_codex":[0.9955288,0.0005085632,0.001656703,0.001287487,0.0004273945,0.0005910898],"domain_scores_gemma":[0.9976725,0.0001286843,0.0006078461,0.0008527249,0.0003528111,0.0003854496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002985922,0.0005725665,0.00002226268,0.001930955,0.001284551,0.000004567381,0.0001844235,0.000003778787,0.006540893,0.00002166848,0.0005549007,0.9858935],"study_design_scores_gemma":[0.007695511,0.01581884,0.00007888523,0.001481352,0.0001717389,0.00004028085,0.00001359475,0.00002381274,0.02214333,0.001342251,0.9497098,0.001480647],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08016834,0.9155582,0.0001745868,0.000015916,0.0001066914,0.003822347,0.00009774675,0.00002309155,0.0000331434],"genre_scores_gemma":[0.001137796,0.9899283,0.005820225,0.0001193309,0.0004340624,0.001165039,0.0007015793,0.0001832537,0.0005104356],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9844128,"threshold_uncertainty_score":0.9996507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2275643592302552,"score_gpt":0.4447940573641431,"score_spread":0.217229698133888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}