{"id":"W2323409804","doi":"10.1152/ajpheart.00033.2003","title":"Changes in amino-terminal portion of human B<sub>2</sub>receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin","year":2003,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Heart, Lung, and Blood Institute","keywords":"Receptor; Kinin; Bradykinin receptor; Agonist; Ligand (biochemistry); Bradykinin; G protein-coupled receptor; Competitive antagonist; Inverse agonist; Chemistry; B2 receptor; Transmembrane protein; Transmembrane domain; Biophysics; Receptor antagonist; Extracellular; Antagonist; Stereochemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020917,0.0002676287,0.0002539304,0.00009340869,0.00008269226,0.0002568154,0.000183988,0.0003131784,0.001523073],"category_scores_gemma":[0.0002279116,0.0001423854,0.0002158047,0.00006773989,0.0002540772,0.0002109116,0.0001406835,0.0005165768,0.0005433614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541969,"about_ca_system_score_gemma":0.0001094679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003026694,"about_ca_topic_score_gemma":0.000393482,"domain_scores_codex":[0.999785,0.00004436087,0.00002916295,0.00004519398,0.00004448873,0.0000518112],"domain_scores_gemma":[0.9998354,0.00005090078,0.00004752699,0.00001918841,0.00001147712,0.0000355258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009564176,0.0000106048,0.00006847376,0.00001172133,0.000003580078,0.00002540415,0.00000417609,0.00002394645,0.9995414,0.00003187735,0.000007774207,0.0001754387],"study_design_scores_gemma":[0.00002476841,0.0003258364,0.002332757,0.000002384818,0.00001708588,0.0003863715,0.00001135702,0.00048307,0.9950631,0.000016803,0.001331477,0.000004965782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982085,0.0005419016,0.0007518868,0.00003800163,0.00001252246,0.000008458931,0.00006849844,0.00002143923,0.0003487651],"genre_scores_gemma":[0.9970282,0.0003529294,0.001656874,0.00006934173,0.00001009926,0.0000150584,0.0002496077,0.00001437532,0.0006036652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523073,"threshold_uncertainty_score":0.005095184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275904695724862,"score_gpt":0.2546365039109265,"score_spread":0.2418774569536778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}