{"id":"W2323441058","doi":"10.1021/jm201335c","title":"Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance Regulator","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Metropolitan University","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; Chemistry; Mutant; Cystic fibrosis; Small molecule; ΔF508; Efflux; Biophysics; Biochemistry; Cell biology; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006663107,0.0003745427,0.0003054957,0.0002784591,0.0002076282,0.0001879846,0.0004229491,0.0006864645,0.002058922],"category_scores_gemma":[0.0006144769,0.0002468948,0.0002560503,0.0002839389,0.0002128695,0.0002768465,0.0001748892,0.0006944282,0.0005252796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489276,"about_ca_system_score_gemma":0.0002160652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003146551,"about_ca_topic_score_gemma":0.0004181082,"domain_scores_codex":[0.9997556,0.00007072525,0.00001506586,0.0000460427,0.00005249698,0.00006019997],"domain_scores_gemma":[0.9996305,0.0001397874,0.00008875756,0.00003814784,0.00005621296,0.00004653884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004472115,0.00001904993,0.00004060867,0.0000513186,0.000003775019,0.0000382978,0.00002607172,0.0001937392,0.9972452,0.0002862815,0.00008002762,0.001970916],"study_design_scores_gemma":[0.0000204252,0.0003109172,0.0003101806,0.000004943939,0.000007504885,0.00007955499,0.000009901385,0.000379776,0.9963208,0.00004353184,0.002504037,0.000008383713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437753,0.004184484,0.04459426,0.0004715209,0.0000975256,0.0003300451,0.0007402144,0.0003133697,0.005493305],"genre_scores_gemma":[0.9594074,0.002212776,0.03050722,0.0002165913,0.00002923795,0.0003480296,0.001049744,0.00006404716,0.006164941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058922,"threshold_uncertainty_score":0.006887794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726707016473816,"score_gpt":0.2645009245696741,"score_spread":0.2372338544049359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}