{"id":"W2323557097","doi":"10.1016/j.juro.2013.02.1710","title":"325 TAK-441, A NOVEL INVESTIGATIONAL SMOOTHENED ANTAGONIST, DELAYS CASTRATION RESISTANT PROGRESSION IN PROSTATE CANCER BY DISRUPTING PARACRINE HEDGEHOG SIGNALING","year":2013,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Smoothened; Paracrine signalling; GLI1; Medicine; Prostate cancer; Hedgehog; Hedgehog signaling pathway; Cancer research; Cancer; Internal medicine; Signal transduction; Biology; Cell biology; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054554,0.0004000606,0.0003351746,0.0004793779,0.000347225,0.000503149,0.0003174949,0.0003782952,0.02707138],"category_scores_gemma":[0.00008898592,0.0002625575,0.0004094658,0.0002450534,0.000176145,0.000399828,0.0002712632,0.001180872,0.006079997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003031803,"about_ca_system_score_gemma":0.0007734494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001335721,"about_ca_topic_score_gemma":0.004509671,"domain_scores_codex":[0.9999117,0.000008634095,0.000006156807,0.000008789982,0.00004117639,0.00002352658],"domain_scores_gemma":[0.9999635,0.000003802604,0.000004769193,0.000002996174,0.000006282351,0.00001854176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.004138124,0.002115301,0.0009851701,0.0009280032,0.0001048608,0.0005819426,0.0001027046,0.0005394808,0.7187421,0.001586596,0.03914998,0.2310258],"study_design_scores_gemma":[0.001895258,0.009685408,0.01371976,0.0001581456,0.0003028375,0.001920181,0.0002163479,0.002045514,0.6370034,0.0007905667,0.3321699,0.0000927915],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6684555,0.1150074,0.009240656,0.008219719,0.003252837,0.0010031,0.008693908,0.003881036,0.1822459],"genre_scores_gemma":[0.6901744,0.07096113,0.007307338,0.002258991,0.0004428736,0.0003863786,0.007136379,0.0002680023,0.2210645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02707138,"threshold_uncertainty_score":0.09056282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629330621761307,"score_gpt":0.2816553920628808,"score_spread":0.2653620858452678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}