{"id":"W2323575454","doi":"10.1021/ja109199p","title":"Turnover Is Rate-Limited by Deglycosylation for Micromonospora viridifaciens Sialidase-Catalyzed Hydrolyses: Conformational Implications for the Michaelis Complex","year":2011,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Sialidase; Michaelis–Menten kinetics; Biochemistry; Catalysis; Stereochemistry; Enzyme; Neuraminidase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004086075,0.0003688135,0.0003215935,0.00009258767,0.0001083945,0.0003938439,0.0003233119,0.0002509206,0.0007028965],"category_scores_gemma":[0.0006117763,0.0002285224,0.0002051066,0.0001256243,0.00026469,0.0004341597,0.000133587,0.0006303786,0.0002131744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006500281,"about_ca_system_score_gemma":0.0002549444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001717721,"about_ca_topic_score_gemma":0.002002284,"domain_scores_codex":[0.9998275,0.00003105045,0.00001105387,0.0000591595,0.00003742415,0.00003370726],"domain_scores_gemma":[0.9997999,0.00007252979,0.0000492525,0.00002135209,0.0000316658,0.00002534576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003392436,0.00002740485,0.001126845,0.00003287387,0.0000128803,0.00002862051,0.00003638878,0.0005813769,0.9941888,0.0002865428,0.0000279408,0.003311045],"study_design_scores_gemma":[0.000007830315,0.0001067717,0.002168836,0.000003142602,0.00001056006,0.00005366861,0.00002179868,0.004061433,0.9930865,0.00007971922,0.000388998,0.00001080968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99647,0.0006161998,0.002193382,0.00003547761,0.000005993381,0.0000074742,0.00009613749,0.00003629857,0.0005391014],"genre_scores_gemma":[0.9977657,0.0003661536,0.00128746,0.00001013217,0.000001436975,0.00000790534,0.0001450026,0.0000122438,0.0004040253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001717721,"threshold_uncertainty_score":0.004716337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04001350519754246,"score_gpt":0.3016291845054842,"score_spread":0.2616156793079417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}