{"id":"W2323588417","doi":"10.1177/095632020001100602","title":"Selection of Resistance-Conferring Mutations in HIV-1 by the Nucleoside Reverse Transcriptase Inhibitors (+/-)dOTC and (+/-)dOTFC","year":2000,"lang":"en","type":"article","venue":"Antiviral chemistry & chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; BioPhage Pharma (Canada); Jewish General Hospital","funders":"Medical Research Council Canada","keywords":"Reverse transcriptase; Resistance mutation; Biology; Mutation; Nucleoside; Virology; Nucleotidyltransferase; Virus; Genotype; Molecular biology; Genetics; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642804,0.0002528804,0.0003207441,0.0001834271,0.0001157756,0.0002911487,0.0001809118,0.0002088361,0.0006751482],"category_scores_gemma":[0.0003024571,0.0001523263,0.0001675219,0.0001793801,0.000112831,0.00009163553,0.0001138638,0.0002398126,0.0001978979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544321,"about_ca_system_score_gemma":0.0001507351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206318,"about_ca_topic_score_gemma":0.001837106,"domain_scores_codex":[0.9997241,0.00005950843,0.0000309012,0.00006515895,0.0000796895,0.00004067647],"domain_scores_gemma":[0.999838,0.00004071432,0.0000508571,0.000024969,0.00002270316,0.00002280313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001029599,0.00003080259,0.0004966966,0.00001336156,0.000007561274,0.00005164394,0.00001360866,0.00008900344,0.9972421,0.00002235749,0.00002510788,0.001904728],"study_design_scores_gemma":[0.00001907644,0.0005599664,0.01004957,0.000003850489,0.00002496096,0.0008315117,0.00001809217,0.0009658573,0.9866371,0.000009835287,0.0008731158,0.000007119323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983235,0.0003562078,0.0004850202,0.00001398819,0.000004379376,0.00002443465,0.0002663897,0.00002710428,0.0004989456],"genre_scores_gemma":[0.9957004,0.0003690641,0.002355649,0.00002176723,0.000005510388,0.00002659271,0.0006451178,0.00002810342,0.0008478748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206318,"threshold_uncertainty_score":0.00239861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00566320649577984,"score_gpt":0.2253073792016228,"score_spread":0.219644172705843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}