{"id":"W2323591096","doi":"10.1093/neuonc/nov061.124","title":"PM-01 * NEURAL DERIVATIVES FROM HUMAN EMBRYONIC STEM CELLS: A CELLULAR SYSTEM TO STUDY THE ROLE OF Otx2 IN MEDULLOBLASTOMA PROGRESSION","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"SOX2; Homeobox protein NANOG; Biology; Sonic hedgehog; Neural stem cell; Embryonic stem cell; Medulloblastoma; H3K4me3; KLF4; Cancer research; Wnt signaling pathway; Induced pluripotent stem cell; Tumor initiation; Stem cell; Chromatin immunoprecipitation; Cell biology; Gene; Genetics; Promoter; Gene expression; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082902,0.0005035151,0.0003212788,0.0004079645,0.0002462018,0.0004058254,0.0005045451,0.0004698103,0.005159484],"category_scores_gemma":[0.0001662054,0.0002626782,0.0003425825,0.0002857936,0.0002423245,0.0002575191,0.0003607188,0.001275453,0.002331443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002670624,"about_ca_system_score_gemma":0.000274918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008979428,"about_ca_topic_score_gemma":0.001219005,"domain_scores_codex":[0.9996814,0.00005668948,0.00003815619,0.00007138037,0.0001159785,0.00003647547],"domain_scores_gemma":[0.9997664,0.00006190262,0.00003368021,0.00006374342,0.00001999311,0.00005417253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002577779,0.0001247931,0.0002411215,0.00006590381,0.000009431793,0.0001807819,0.00003155972,0.00009835441,0.9942074,0.0006557402,0.0004326442,0.003694447],"study_design_scores_gemma":[0.00006284213,0.00097061,0.004009123,0.00001552729,0.00002986272,0.0008956246,0.00003382421,0.001276079,0.9589176,0.0001334694,0.03364861,0.000006848352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9017801,0.005330687,0.03013382,0.0007819941,0.0004915104,0.0008809638,0.01491649,0.001276173,0.04440835],"genre_scores_gemma":[0.8885111,0.002790628,0.02667116,0.0003430026,0.00007456404,0.0008618287,0.02074034,0.0004231986,0.05958432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005159484,"threshold_uncertainty_score":0.01726025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02587982666059471,"score_gpt":0.3117997425379992,"score_spread":0.2859199158774045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}